From macroprolactinoma to concomitant ACTH-PRL hypersecretion with Cushing's disease

M. Barausse, R. Attanasio, D. Dallabonzana, G. Oppizzi, S. Veronese, G. Lasio, L. G. Valentini, R. Cozzi

Research output: Contribution to journalArticlepeer-review


Multiple pituitary hormone hypersecretions have been already described, but the combination of PRL and ACTH excess is rare. This report deals with a 42-yr-old woman affected by macroprolactinoma (PRL 12,720 μg/l, huge tumor with extrasellar extension at imaging). After one year on dopaminergic treatment causing PRL normalization and tumor shrinkage, she developed hypercortisolism (UFC 1,000 μg/24 h, ACTH 200 ng/l). Cushing's disease was diagnosed. After neurosurgery (at immunocytochemistry mixed ACTH-PRL adenoma was shown) hypercortisolism remitted, whereas pathological hyperprolactinemia with tumor remnant in cavernous sinus persisted and hypopituitarism developed. The patient reported seems atypical for the following reasons: 1) the concomitant PRL and ACTH hypersecretions; 2) the clinical presentation with hypercortisolism following hyperprolactinemia; 3) the surgical cure of hypercortisolism with persisting hyperprolactinemia. (C)2000, Editrice Kurtis.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number2
Publication statusPublished - 2000


  • Cushing's disease
  • Hyperprolactinemia
  • Macroadenoma
  • Mixed adenoma

ASJC Scopus subject areas

  • Endocrinology


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