TY - JOUR
T1 - From neurophysiology to genetics
T2 - Cortical information processing in migraine underlies familial influences - A novel approach
AU - Sándor, P. S.
AU - Áfra, J.
AU - Cecchini, A. P.
AU - Albert, A.
AU - Schoenen, J.
PY - 2000
Y1 - 2000
N2 - Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. VEP-habituation and IDAP were studied in 40 migraine patients, i.e. pairs of 20 parents and their children. We developed a novel approach based on Monte Carlo statistics to selectively assess vertical familial influences. Both groups, parents and children, were characterized by abnormal VEP-habituation and IDAP. However, similarity between related pairs was far more pronounced than similarity between unrelated pairs. Assessed with a novel statistical approach, familial influences proved to be highly significant in determining cortical information processing in migraineurs, thus supporting the important role of genetic factors.
AB - Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. VEP-habituation and IDAP were studied in 40 migraine patients, i.e. pairs of 20 parents and their children. We developed a novel approach based on Monte Carlo statistics to selectively assess vertical familial influences. Both groups, parents and children, were characterized by abnormal VEP-habituation and IDAP. However, similarity between related pairs was far more pronounced than similarity between unrelated pairs. Assessed with a novel statistical approach, familial influences proved to be highly significant in determining cortical information processing in migraineurs, thus supporting the important role of genetic factors.
KW - Evoked potentials
KW - Genetics
KW - Habituation
KW - Migraine
KW - Monte Carlo statistics
UR - http://www.scopus.com/inward/record.url?scp=0034521486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034521486&partnerID=8YFLogxK
M3 - Article
C2 - 11200803
AN - SCOPUS:0034521486
VL - 15
SP - 68
EP - 72
JO - Functional Neurology
JF - Functional Neurology
SN - 0393-5264
IS - 3 SUPPL.
ER -