From pathogenesis to personalized treatments of neuropathies in hematological malignancies

Chiara Briani, Andrea Visentin, Federica Cerri, Angelo Quattrini

Research output: Contribution to journalReview articlepeer-review

Abstract

The peripheral nervous system may be involved at any stage in the course of several hematological diseases, the most common being monoclonal gammopathies (of undetermined significance or malignant) or lymphomas. The underlying pathogenic mechanisms are different and therapies aim at targeting the dangerous either B-cell or plasma cell clones. Recently, high-throughput technologies, and next-generation sequencing have increased our knowledge of hematological diseases pathogenesis by the identification of somatic mutation affecting pivotal signaling pathways. Accordingly, new target therapies are used that may also be borrowed for treatment of neuropathies in hematological diseases.

Original languageEnglish
Pages (from-to)212-221
Number of pages10
JournalJournal of the Peripheral Nervous System
Volume25
Issue number3
DOIs
Publication statusPublished - Sep 1 2020

Keywords

  • ibrutinib
  • lymphoma
  • monoclonal gammopathy
  • neurolymphomatosis
  • neuropathy
  • obinutuzumab
  • rituximab

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'From pathogenesis to personalized treatments of neuropathies in hematological malignancies'. Together they form a unique fingerprint.

Cite this