From primary progressive aphasia to corticobasal syndrome: Two clinical and rCBF functional reports

Francesca Caso, F. Onofrio, M. Falautano, P. Todeschini, R. Migliaccio, G. Comi, D. Perani, G. Magnani

Research output: Contribution to journalArticlepeer-review

Abstract

We describe two cases, both presenting with a 2-year history of isolated language disorders, one compatible with logopenic variant and the other with non-fluent variant of primary progressive aphasia (PPA). Afterwards, each developed a corticobasal syndrome (CBS) with alien limb phenomenon and a multi-domain cognitive impairment. Regional cerebral perfusion (rCBF) study using 99mTc-ECD single photon emission computed tomography (SPECT) revealed hypoperfusion patterns consistent with these aphasia types and with the presence of limb apraxia. We report two cases of PPA variants associated with CBS and we suggest that SPECT rCBF correlates can be useful in making a differential diagnosis within the PPA spectrum.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalNeurocase
Volume19
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Corticobasal syndrome
  • Functional imaging
  • Logopenic variant of primary progressive aphasia
  • Non-fluent variant of primary progressive aphasia
  • Primary progressive aphasia

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

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