From 'real' pharmacotherapeutic problems in schizophrenia to an 'ideal' pharmacodynamic profile for neuroleptics

A. C. Altamura

doi:10.1016/0924-977X(94)90049-3

From 'real' pharmacotherapeutic problems in schizophrenia to an 'ideal' pharmacodynamic profile for neuroleptics

A. C. Altamura

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The 'ideal' pharmacodynamic profile of a neuroleptic stems from the neurochemical data indicating an involvement of not just D2 receptors but also other DA, 5-HT and glutamate receptors in the pathogenesis of schizophrenia. Moreover, this 'ideal' drug should lack anticholinergic and α-adrenolytic activity. A broader spectrum of clinical activity and a better tolerability could be expected.

Original language	English
Pages (from-to)	219-220
Number of pages	2
Journal	European Neuropsychopharmacology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/0924-977X(94)90049-3
Publication status	Published - 1994

Keywords

DA receptors subtypes
Drug resistance
Drug treatment
Schizophrenia
Serotonin

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Neurology
Pharmacology
Psychology(all)

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Cite this

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From 'real' pharmacotherapeutic problems in schizophrenia to an 'ideal' pharmacodynamic profile for neuroleptics

Abstract

Keywords

ASJC Scopus subject areas

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