Abstract
The 'ideal' pharmacodynamic profile of a neuroleptic stems from the neurochemical data indicating an involvement of not just D2 receptors but also other DA, 5-HT and glutamate receptors in the pathogenesis of schizophrenia. Moreover, this 'ideal' drug should lack anticholinergic and α-adrenolytic activity. A broader spectrum of clinical activity and a better tolerability could be expected.
Original language | English |
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Pages (from-to) | 219-220 |
Number of pages | 2 |
Journal | European Neuropsychopharmacology |
Volume | 4 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1994 |
Keywords
- DA receptors subtypes
- Drug resistance
- Drug treatment
- Schizophrenia
- Serotonin
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
- Neurology
- Pharmacology
- Psychology(all)