From the bench to the bed: Individualizing treatment in non-small-cell lung cancer

Mariacarmela Santarpia, Giuseppe Altavilla, Fernanda Salazar, Miquel Tarón, Rafael Rosell

Research output: Contribution to journalArticlepeer-review

Abstract

At the time of diagnosis, half of lung cancer patients have advanced incurable disease. Different chemotherapy combinations-with or without targeted therapies-yield similar results in spite of the continuous efforts of clinicians. However, molecular biological studies have already shed a great deal of light on the existence of multiple genetic aberrations that can be useful for customizing treatment, mRNA transcripts involved in DNA repair pathways, such as ERCC1 and BRCA1, confer selective resistance to cisplatin or taxanes. Polymorphisms in DNA repair genes and methylation of checkpoint genes in circulating serum DNA could become important predictive markers of survival to certain cisplatin-based regimens. EGFR tyrosine kinase mutations are the crux of targeted therapies.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalClinical and Translational Oncology
Volume8
Issue number2
DOIs
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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