From the discovery of monoclonal antibodies to their therapeutic application: An historical reappraisal

Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Vertebrate make billions of different antibodies, each with a binding site that recognizes a specific region of a macromolecule. The hybridoma technique allows monoclonal antibodies, highly specific antibodies produced in the laboratory by a variety of methods. In the last 35 years since the first process for creating monoclonal antibodies was introduced, their application have improved the growing biotechnology industry, but the most important application concerns the therapy of human malignancies.

Original languageEnglish
Pages (from-to)96-99
Number of pages4
JournalImmunology Letters
Volume161
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Cancer
  • History of medicine
  • Immunology
  • Monoclonal antibodies
  • Therapy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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