From transcriptome to noncoding RNAs: Implications in ALS mechanism

Stella Gagliardi, Pamela Milani, Valentina Sardone, Orietta Pansarasa, Cristina Cereda

Research output: Contribution to journalArticle

Abstract

In the last years, numerous studies have focused on understanding the metabolism of RNA and its implication in disease processes but abnormal RNA metabolism is still unknown. RNA plays a central role in translating genetic information into proteins and in many other catalytic and regulatory tasks. Recent advances in the study of RNA metabolism revealed complex pathways for the generation and maintenance of functional RNA in amyotrophic lateral sclerosis (ALS). Interestingly, perturbations in RNA processing have been described in ALS at various levels such as gene transcription, mRNA stabilization, transport, and translational regulations. In this paper, we will discuss the alteration of RNA profile in ALS disease, starting from transcription, the first step leading to gene expression, through the posttranscriptional regulation, including RNA/DNA binding proteins and aberrant exon splicing to protein noncoding RNAs, as lncRNA and microRNA.

Original languageEnglish
Article number278725
JournalNeurology Research International
Volume2012
DOIs
Publication statusPublished - 2012

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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