Abstract
In the last years, numerous studies have focused on understanding the metabolism of RNA and its implication in disease processes but abnormal RNA metabolism is still unknown. RNA plays a central role in translating genetic information into proteins and in many other catalytic and regulatory tasks. Recent advances in the study of RNA metabolism revealed complex pathways for the generation and maintenance of functional RNA in amyotrophic lateral sclerosis (ALS). Interestingly, perturbations in RNA processing have been described in ALS at various levels such as gene transcription, mRNA stabilization, transport, and translational regulations. In this paper, we will discuss the alteration of RNA profile in ALS disease, starting from transcription, the first step leading to gene expression, through the posttranscriptional regulation, including RNA/DNA binding proteins and aberrant exon splicing to protein noncoding RNAs, as lncRNA and microRNA.
| Original language | English |
|---|---|
| Article number | 278725 |
| Journal | Neurology Research International |
| Volume | 2012 |
| DOIs | |
| Publication status | Published - 2012 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
From transcriptome to noncoding RNAs : Implications in ALS mechanism. / Gagliardi, Stella; Milani, Pamela; Sardone, Valentina; Pansarasa, Orietta; Cereda, Cristina.
In: Neurology Research International, Vol. 2012, 278725, 2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - From transcriptome to noncoding RNAs
T2 - Implications in ALS mechanism
AU - Gagliardi, Stella
AU - Milani, Pamela
AU - Sardone, Valentina
AU - Pansarasa, Orietta
AU - Cereda, Cristina
PY - 2012
Y1 - 2012
N2 - In the last years, numerous studies have focused on understanding the metabolism of RNA and its implication in disease processes but abnormal RNA metabolism is still unknown. RNA plays a central role in translating genetic information into proteins and in many other catalytic and regulatory tasks. Recent advances in the study of RNA metabolism revealed complex pathways for the generation and maintenance of functional RNA in amyotrophic lateral sclerosis (ALS). Interestingly, perturbations in RNA processing have been described in ALS at various levels such as gene transcription, mRNA stabilization, transport, and translational regulations. In this paper, we will discuss the alteration of RNA profile in ALS disease, starting from transcription, the first step leading to gene expression, through the posttranscriptional regulation, including RNA/DNA binding proteins and aberrant exon splicing to protein noncoding RNAs, as lncRNA and microRNA.
AB - In the last years, numerous studies have focused on understanding the metabolism of RNA and its implication in disease processes but abnormal RNA metabolism is still unknown. RNA plays a central role in translating genetic information into proteins and in many other catalytic and regulatory tasks. Recent advances in the study of RNA metabolism revealed complex pathways for the generation and maintenance of functional RNA in amyotrophic lateral sclerosis (ALS). Interestingly, perturbations in RNA processing have been described in ALS at various levels such as gene transcription, mRNA stabilization, transport, and translational regulations. In this paper, we will discuss the alteration of RNA profile in ALS disease, starting from transcription, the first step leading to gene expression, through the posttranscriptional regulation, including RNA/DNA binding proteins and aberrant exon splicing to protein noncoding RNAs, as lncRNA and microRNA.
UR - http://www.scopus.com/inward/record.url?scp=84866148205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866148205&partnerID=8YFLogxK
U2 - 10.1155/2012/278725
DO - 10.1155/2012/278725
M3 - Article
C2 - 22778949
AN - SCOPUS:84866148205
VL - 2012
JO - Neurology Research International
JF - Neurology Research International
SN - 2090-1852
M1 - 278725
ER -