Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Roberto Marconi, Angelo Antonini, Paolo Barone, Carlo Colosimo, Tania P. Avarello, Edo Bottacchi, Antonino Cannas, Maria G. Ceravolo, Roberto Ceravolo, Giulio Cicarelli, Rosa M. Gaglio, Luisa Giglia, Francesco Iemolo, Michela Manfredi, Giuseppe Meco, Alessandra Nicoletti, Massimo Pederzoli, Alfredo Petrone, Antonio Pisani, Francesco E. PontieriRocco Quatrale, Silvia Ramat, Rossana Scala, Giampiero Volpe, Salvatore Zappulla, Anna Rita Bentivoglio, Fabrizio Stocchi, Giorgio Trianni, Paolo Del Dotto, Danilo De Gaspari, Lucia Grasso, Francesca Morgante, Gabriella Santangelo, Giovanni Fabbrini, Letterio Morgante

Research output: Contribution to journalArticle


Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score B23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score B13.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L-DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (≤ B -0.16) and age with all FAB items but prehension On behalf of the PRIAMO study group. behavior (≤ B -0.01). Previous use of L-DOPA was.

Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalNeurological Sciences
Issue number3
Publication statusPublished - Jun 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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