Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation

Fiammetta Monacelli, Lucia Martella, Maria Nives Parodi, Patrizio Odetti, Francesca Fanelli, Massimo Tabaton

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease may mimic frontotemporal dementia. We describe a case of presenile dementia who presented with peudo-psychotic symptoms carrying a PSEN1 mutation (P355S), which was not known to be pathogenic. PET-FDG showed bilateral frontotemporal hypometabolism, but at MRI, multiple microbleeds were detected, suggestive of amyloid angiopathy.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalJournal of Alzheimer's Disease
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Alzheimer Disease
Frontotemporal Dementia
Mutation
Amyloid angiopathy

Keywords

  • Behavioral variant
  • presenile dementia
  • presenilin 1 mutation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Frontal Variant of Alzheimer's Disease : A Report of a Novel PSEN1 Mutation. / Monacelli, Fiammetta; Martella, Lucia; Parodi, Maria Nives; Odetti, Patrizio; Fanelli, Francesca; Tabaton, Massimo.

In: Journal of Alzheimer's Disease, Vol. 70, No. 1, 01.01.2019, p. 11-15.

Research output: Contribution to journalArticle

Monacelli, Fiammetta ; Martella, Lucia ; Parodi, Maria Nives ; Odetti, Patrizio ; Fanelli, Francesca ; Tabaton, Massimo. / Frontal Variant of Alzheimer's Disease : A Report of a Novel PSEN1 Mutation. In: Journal of Alzheimer's Disease. 2019 ; Vol. 70, No. 1. pp. 11-15.
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