Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation

Fiammetta Monacelli, Lucia Martella, Maria Nives Parodi, Patrizio Odetti, Francesca Fanelli, Massimo Tabaton

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer's disease may mimic frontotemporal dementia. We describe a case of presenile dementia who presented with peudo-psychotic symptoms carrying a PSEN1 mutation (P355S), which was not known to be pathogenic. PET-FDG showed bilateral frontotemporal hypometabolism, but at MRI, multiple microbleeds were detected, suggestive of amyloid angiopathy.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalJournal of Alzheimer's Disease
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Behavioral variant
  • presenile dementia
  • presenilin 1 mutation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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