Fronto-parietal areas necessary for a multisensory representation of peripersonal space in humans: An rTMS study

Andrea Serino, Elisa Canzoneri, Alessio Avenanti

Research output: Contribution to journalArticle

Abstract

A network of brain regions including the ventral premotor cortex (vPMc) and the posterior parietal cortex (PPc) is consistently recruited during processing of multisensory stimuli within peripersonal space (PPS). However, to date, information on the causal role of these fronto-parietal areas in multisensory PPS representation is lacking. Using low-frequency repetitive TMS (rTMS; 1 Hz), we induced transient virtual lesions to the left vPMc, PPc, and visual cortex (V1, control site) and tested whether rTMS affected audio-tactile interaction in the PPS around the hand. Subjects performed a timed response task to a tactile stimulus on their right (contralateral to rTMS) hand while concurrent task-irrelevant sounds were presented either close to the hand or 1mfar from the hand. When no rTMS was delivered, a sound close to the hand reduced RT-totactile targets as compared with when a far sound was presented. This space-dependent, auditory modulation of tactile perception was specific to a hand-centered reference frame. Such a specific form of multisensory interaction near the hand can be taken as a behavioral hallmark of PPS representation. Crucially, virtual lesions to vPMc and PPc, but not to V1, eliminated the speeding effect due to near sounds, showing a disruption of audio-tactile interactions around the hand. These findings indicate thatmultisensory interaction around the hand depends on the functions of vPMc and PPc, thus pointing to the necessity of this human fronto-parietal network in multisensory representation of PPS.

Original languageEnglish
Pages (from-to)2956-2967
Number of pages12
JournalJournal of Cognitive Neuroscience
Volume23
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Hand
Parietal Lobe
Motor Cortex
Touch
Touch Perception
Visual Cortex
Brain

ASJC Scopus subject areas

  • Cognitive Neuroscience

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Fronto-parietal areas necessary for a multisensory representation of peripersonal space in humans : An rTMS study. / Serino, Andrea; Canzoneri, Elisa; Avenanti, Alessio.

In: Journal of Cognitive Neuroscience, Vol. 23, No. 10, 10.2011, p. 2956-2967.

Research output: Contribution to journalArticle

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