Frozen IVF Cycles to Circumvent the Hormonal Storm on Endometrium

Paola Viganò, Alessandra Alteri, Andrea Busnelli, Valeria Stella Vanni, Edgardo Somigliana

Research output: Contribution to journalReview articlepeer-review


Controlled ovarian hyperstimulation (COH) determines an anticipation of endometrial maturation and a premature occurrence of the implantation window, as shown by histological, histochemical, and molecular studies and indirectly by clinical trials. There is growing agreement that in patients hyper-responding to COH and in those undergoing transfer at the blastocyst stage, deferring the transfer in a subsequent frozen cycle could increase pregnancy outcomes. For blastocysts, implantation after a fresh transfer may be limited as the implantation window is already closed while, in hyper-responders to COH, the anticipation magnitude could be more marked thus hampering implantation also for cleavage-stage embryos. Research should focus in depth on pregnancy outcomes and on the most suitable modality to prepare the endometrium for frozen transfers.

Original languageEnglish
Pages (from-to)296-307
Number of pages12
JournalTrends in Endocrinology and Metabolism
Issue number4
Publication statusPublished - Apr 2020


  • controlled ovarian hyperstimulation
  • endometrium
  • frozen cycles
  • IVF

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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