Frozen IVF Cycles to Circumvent the Hormonal Storm on Endometrium: Trends in Endocrinology and Metabolism

P. Viganò, A. Alteri, A. Busnelli, V.S. Vanni, E. Somigliana

Research output: Contribution to journalArticlepeer-review


Controlled ovarian hyperstimulation (COH) determines an anticipation of endometrial maturation and a premature occurrence of the implantation window, as shown by histological, histochemical, and molecular studies and indirectly by clinical trials. There is growing agreement that in patients hyper-responding to COH and in those undergoing transfer at the blastocyst stage, deferring the transfer in a subsequent frozen cycle could increase pregnancy outcomes. For blastocysts, implantation after a fresh transfer may be limited as the implantation window is already closed while, in hyper-responders to COH, the anticipation magnitude could be more marked thus hampering implantation also for cleavage-stage embryos. Research should focus in depth on pregnancy outcomes and on the most suitable modality to prepare the endometrium for frozen transfers. © 2020 Elsevier Ltd
Original languageEnglish
Pages (from-to)296-307
Number of pages12
JournalTrends Endocrinol. Metab.
Issue number4
Publication statusPublished - 2020


  • controlled ovarian hyperstimulation
  • endometrium
  • frozen cycles
  • IVF
  • blastocyst
  • clinical outcome
  • female
  • freeze thawing
  • human
  • in vitro fertilization
  • large for gestational age
  • meta analysis (topic)
  • nidation
  • nonhuman
  • ovary hyperstimulation
  • preeclampsia
  • pregnancy outcome
  • pregnancy rate
  • priority journal
  • Review
  • systematic review (topic)
  • uterine receptivity
  • uterus function


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