Abstract
Controlled ovarian hyperstimulation (COH) determines an anticipation of endometrial maturation and a premature occurrence of the implantation window, as shown by histological, histochemical, and molecular studies and indirectly by clinical trials. There is growing agreement that in patients hyper-responding to COH and in those undergoing transfer at the blastocyst stage, deferring the transfer in a subsequent frozen cycle could increase pregnancy outcomes. For blastocysts, implantation after a fresh transfer may be limited as the implantation window is already closed while, in hyper-responders to COH, the anticipation magnitude could be more marked thus hampering implantation also for cleavage-stage embryos. Research should focus in depth on pregnancy outcomes and on the most suitable modality to prepare the endometrium for frozen transfers. © 2020 Elsevier Ltd
Original language | English |
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Pages (from-to) | 296-307 |
Number of pages | 12 |
Journal | Trends Endocrinol. Metab. |
Volume | 31 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- controlled ovarian hyperstimulation
- endometrium
- frozen cycles
- IVF
- blastocyst
- clinical outcome
- female
- freeze thawing
- human
- in vitro fertilization
- large for gestational age
- meta analysis (topic)
- nidation
- nonhuman
- ovary hyperstimulation
- preeclampsia
- pregnancy outcome
- pregnancy rate
- priority journal
- Review
- systematic review (topic)
- uterine receptivity
- uterus function