Fructosamine, glycated hemoglobin, and dietary carbohydrates

Giovanni Misciagna, Giancarlo Logroscino, Giampietro De Michele, Anna M. Cisternino, Vito Guerra, Jo L. Freudenheim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Glycated hemoglobin (HbA1c), a marker of glycemia in the previous 3 months, was found to be associated with dietary saturated, fat but not with carbohydrates, in recent population surveys. Another nonenzymatically glycated substance in the blood, fructosamine, a marker of glycemia in the previous 3 weeks, is poorly correlated with HbA1c in nondiabetic subjects. The aim of this study is to compare the correlation of glycated hemoglobin and fructosamine with dietary carbohydrate intake in the same subjects. Subjects and methods: Seventy-one individuals from a cohort study on diet and cancer entered this study. Serum fructosamine was measured by a standard colorimetric method, and glycated hemoglobin by high-performance liquid chromatography (HPLC). Diet was measured by a validated semiquantitative food frequency questionnaire. The correlation of fructosamine and glycated hemoglobin with dietary variables, corrected for calories, was evaluated by multiple correlation. Results: Fructosamine was more strongly correlated with dietary sugar (r=0.26, p=0.05) than HbA1c was (r=0.001, p=0.99). Fructosamine was also inversely correlated with energy, and glycated hemoglobin with vitamin C. Conclusions: Fructosamine appears to be more related to dietary sugar intake than glycated hemoglobin and may be a marker of exposure to dietary carbohydrates, particularly simple sugars, in epidemiological studies.

Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalClinica Chimica Acta
Volume340
Issue number1-2
DOIs
Publication statusPublished - Feb 2004

Fingerprint

Fructosamine
Dietary Carbohydrates
Glycosylated Hemoglobin A
Dietary Sucrose
Nutrition
Diet
Dietary Fats
High performance liquid chromatography
Sugars
Ascorbic Acid
Epidemiologic Studies
Blood
Cohort Studies
Fats
High Pressure Liquid Chromatography
Carbohydrates
Food
Serum

Keywords

  • Dietary carbohydrates
  • Fructosamine
  • Glycated hemoglobin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Misciagna, G., Logroscino, G., De Michele, G., Cisternino, A. M., Guerra, V., & Freudenheim, J. L. (2004). Fructosamine, glycated hemoglobin, and dietary carbohydrates. Clinica Chimica Acta, 340(1-2), 139-147. https://doi.org/10.1016/j.cccn.2003.10.024

Fructosamine, glycated hemoglobin, and dietary carbohydrates. / Misciagna, Giovanni; Logroscino, Giancarlo; De Michele, Giampietro; Cisternino, Anna M.; Guerra, Vito; Freudenheim, Jo L.

In: Clinica Chimica Acta, Vol. 340, No. 1-2, 02.2004, p. 139-147.

Research output: Contribution to journalArticle

Misciagna, G, Logroscino, G, De Michele, G, Cisternino, AM, Guerra, V & Freudenheim, JL 2004, 'Fructosamine, glycated hemoglobin, and dietary carbohydrates', Clinica Chimica Acta, vol. 340, no. 1-2, pp. 139-147. https://doi.org/10.1016/j.cccn.2003.10.024
Misciagna G, Logroscino G, De Michele G, Cisternino AM, Guerra V, Freudenheim JL. Fructosamine, glycated hemoglobin, and dietary carbohydrates. Clinica Chimica Acta. 2004 Feb;340(1-2):139-147. https://doi.org/10.1016/j.cccn.2003.10.024
Misciagna, Giovanni ; Logroscino, Giancarlo ; De Michele, Giampietro ; Cisternino, Anna M. ; Guerra, Vito ; Freudenheim, Jo L. / Fructosamine, glycated hemoglobin, and dietary carbohydrates. In: Clinica Chimica Acta. 2004 ; Vol. 340, No. 1-2. pp. 139-147.
@article{eb8d9fb283e047638b1e5c56bc5824bd,
title = "Fructosamine, glycated hemoglobin, and dietary carbohydrates",
abstract = "Background: Glycated hemoglobin (HbA1c), a marker of glycemia in the previous 3 months, was found to be associated with dietary saturated, fat but not with carbohydrates, in recent population surveys. Another nonenzymatically glycated substance in the blood, fructosamine, a marker of glycemia in the previous 3 weeks, is poorly correlated with HbA1c in nondiabetic subjects. The aim of this study is to compare the correlation of glycated hemoglobin and fructosamine with dietary carbohydrate intake in the same subjects. Subjects and methods: Seventy-one individuals from a cohort study on diet and cancer entered this study. Serum fructosamine was measured by a standard colorimetric method, and glycated hemoglobin by high-performance liquid chromatography (HPLC). Diet was measured by a validated semiquantitative food frequency questionnaire. The correlation of fructosamine and glycated hemoglobin with dietary variables, corrected for calories, was evaluated by multiple correlation. Results: Fructosamine was more strongly correlated with dietary sugar (r=0.26, p=0.05) than HbA1c was (r=0.001, p=0.99). Fructosamine was also inversely correlated with energy, and glycated hemoglobin with vitamin C. Conclusions: Fructosamine appears to be more related to dietary sugar intake than glycated hemoglobin and may be a marker of exposure to dietary carbohydrates, particularly simple sugars, in epidemiological studies.",
keywords = "Dietary carbohydrates, Fructosamine, Glycated hemoglobin",
author = "Giovanni Misciagna and Giancarlo Logroscino and {De Michele}, Giampietro and Cisternino, {Anna M.} and Vito Guerra and Freudenheim, {Jo L.}",
year = "2004",
month = "2",
doi = "10.1016/j.cccn.2003.10.024",
language = "English",
volume = "340",
pages = "139--147",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Fructosamine, glycated hemoglobin, and dietary carbohydrates

AU - Misciagna, Giovanni

AU - Logroscino, Giancarlo

AU - De Michele, Giampietro

AU - Cisternino, Anna M.

AU - Guerra, Vito

AU - Freudenheim, Jo L.

PY - 2004/2

Y1 - 2004/2

N2 - Background: Glycated hemoglobin (HbA1c), a marker of glycemia in the previous 3 months, was found to be associated with dietary saturated, fat but not with carbohydrates, in recent population surveys. Another nonenzymatically glycated substance in the blood, fructosamine, a marker of glycemia in the previous 3 weeks, is poorly correlated with HbA1c in nondiabetic subjects. The aim of this study is to compare the correlation of glycated hemoglobin and fructosamine with dietary carbohydrate intake in the same subjects. Subjects and methods: Seventy-one individuals from a cohort study on diet and cancer entered this study. Serum fructosamine was measured by a standard colorimetric method, and glycated hemoglobin by high-performance liquid chromatography (HPLC). Diet was measured by a validated semiquantitative food frequency questionnaire. The correlation of fructosamine and glycated hemoglobin with dietary variables, corrected for calories, was evaluated by multiple correlation. Results: Fructosamine was more strongly correlated with dietary sugar (r=0.26, p=0.05) than HbA1c was (r=0.001, p=0.99). Fructosamine was also inversely correlated with energy, and glycated hemoglobin with vitamin C. Conclusions: Fructosamine appears to be more related to dietary sugar intake than glycated hemoglobin and may be a marker of exposure to dietary carbohydrates, particularly simple sugars, in epidemiological studies.

AB - Background: Glycated hemoglobin (HbA1c), a marker of glycemia in the previous 3 months, was found to be associated with dietary saturated, fat but not with carbohydrates, in recent population surveys. Another nonenzymatically glycated substance in the blood, fructosamine, a marker of glycemia in the previous 3 weeks, is poorly correlated with HbA1c in nondiabetic subjects. The aim of this study is to compare the correlation of glycated hemoglobin and fructosamine with dietary carbohydrate intake in the same subjects. Subjects and methods: Seventy-one individuals from a cohort study on diet and cancer entered this study. Serum fructosamine was measured by a standard colorimetric method, and glycated hemoglobin by high-performance liquid chromatography (HPLC). Diet was measured by a validated semiquantitative food frequency questionnaire. The correlation of fructosamine and glycated hemoglobin with dietary variables, corrected for calories, was evaluated by multiple correlation. Results: Fructosamine was more strongly correlated with dietary sugar (r=0.26, p=0.05) than HbA1c was (r=0.001, p=0.99). Fructosamine was also inversely correlated with energy, and glycated hemoglobin with vitamin C. Conclusions: Fructosamine appears to be more related to dietary sugar intake than glycated hemoglobin and may be a marker of exposure to dietary carbohydrates, particularly simple sugars, in epidemiological studies.

KW - Dietary carbohydrates

KW - Fructosamine

KW - Glycated hemoglobin

UR - http://www.scopus.com/inward/record.url?scp=0842281430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842281430&partnerID=8YFLogxK

U2 - 10.1016/j.cccn.2003.10.024

DO - 10.1016/j.cccn.2003.10.024

M3 - Article

VL - 340

SP - 139

EP - 147

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

IS - 1-2

ER -