Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Sabine Rohrmann, Nikolaus Becker, Jakob Linseisen, Alexandra Nieters, Thomas Rüdiger, Ole Raaschou-Nielsen, Anne Tjønneland, Hans E. Johnsen, Kim Overvad, Rudolf Kaaks, Manuela M. Bergmann, Heiner Boeing, Vasiliki Benetou, Theodora Psaltopoulou, Antonia Trichopoulou, Giovanna Masala, Amalia Mattiello, Vittorio Krogh, Rosario Tumino, Carla H Van GilsPetra H M Peeters, H. Bas Bueno-De-Mesquita, Martine M. Ros, Eiliv Lund, Eva Ardanaz, María Dolores Chirlaque, Paula Jakszyn, Nerea Larrañaga, A. Losada, Carmen Martínez-García, Åsa Ågren, Göran Hallmans, Göran Berglund, Jonas Manjer, Naomi E. Allen, Timothy J. Key, Sheila Bingham, Kay Tee Khaw, Nadia Slimani, Pietro Ferrari, Paolo Boffetta, Teresa Norat, Paolo Vineis, Elio Riboli

Research output: Contribution to journalArticle

Abstract

Introduction: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. Material and methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and subentities. Results: There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95, 95% confidence interval (CI) 0.78-1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95% CI 0.23-1.02). Conclusion: In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation.

Original languageEnglish
Pages (from-to)537-549
Number of pages13
JournalCancer Causes and Control
Volume18
Issue number5
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Vegetables
Fruit
Lymphoma
Neoplasms
Lymphoma, Large B-Cell, Diffuse
Confidence Intervals
Immune System Diseases
Proportional Hazards Models
Habits
Life Style
Prospective Studies

Keywords

  • Cohort study
  • Fruits
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Vegetables

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Rohrmann, S., Becker, N., Linseisen, J., Nieters, A., Rüdiger, T., Raaschou-Nielsen, O., ... Riboli, E. (2007). Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes and Control, 18(5), 537-549. https://doi.org/10.1007/s10552-007-0125-z

Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Rohrmann, Sabine; Becker, Nikolaus; Linseisen, Jakob; Nieters, Alexandra; Rüdiger, Thomas; Raaschou-Nielsen, Ole; Tjønneland, Anne; Johnsen, Hans E.; Overvad, Kim; Kaaks, Rudolf; Bergmann, Manuela M.; Boeing, Heiner; Benetou, Vasiliki; Psaltopoulou, Theodora; Trichopoulou, Antonia; Masala, Giovanna; Mattiello, Amalia; Krogh, Vittorio; Tumino, Rosario; Gils, Carla H Van; Peeters, Petra H M; Bueno-De-Mesquita, H. Bas; Ros, Martine M.; Lund, Eiliv; Ardanaz, Eva; Chirlaque, María Dolores; Jakszyn, Paula; Larrañaga, Nerea; Losada, A.; Martínez-García, Carmen; Ågren, Åsa; Hallmans, Göran; Berglund, Göran; Manjer, Jonas; Allen, Naomi E.; Key, Timothy J.; Bingham, Sheila; Khaw, Kay Tee; Slimani, Nadia; Ferrari, Pietro; Boffetta, Paolo; Norat, Teresa; Vineis, Paolo; Riboli, Elio.

In: Cancer Causes and Control, Vol. 18, No. 5, 06.2007, p. 537-549.

Research output: Contribution to journalArticle

Rohrmann, S, Becker, N, Linseisen, J, Nieters, A, Rüdiger, T, Raaschou-Nielsen, O, Tjønneland, A, Johnsen, HE, Overvad, K, Kaaks, R, Bergmann, MM, Boeing, H, Benetou, V, Psaltopoulou, T, Trichopoulou, A, Masala, G, Mattiello, A, Krogh, V, Tumino, R, Gils, CHV, Peeters, PHM, Bueno-De-Mesquita, HB, Ros, MM, Lund, E, Ardanaz, E, Chirlaque, MD, Jakszyn, P, Larrañaga, N, Losada, A, Martínez-García, C, Ågren, Å, Hallmans, G, Berglund, G, Manjer, J, Allen, NE, Key, TJ, Bingham, S, Khaw, KT, Slimani, N, Ferrari, P, Boffetta, P, Norat, T, Vineis, P & Riboli, E 2007, 'Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)', Cancer Causes and Control, vol. 18, no. 5, pp. 537-549. https://doi.org/10.1007/s10552-007-0125-z
Rohrmann, Sabine ; Becker, Nikolaus ; Linseisen, Jakob ; Nieters, Alexandra ; Rüdiger, Thomas ; Raaschou-Nielsen, Ole ; Tjønneland, Anne ; Johnsen, Hans E. ; Overvad, Kim ; Kaaks, Rudolf ; Bergmann, Manuela M. ; Boeing, Heiner ; Benetou, Vasiliki ; Psaltopoulou, Theodora ; Trichopoulou, Antonia ; Masala, Giovanna ; Mattiello, Amalia ; Krogh, Vittorio ; Tumino, Rosario ; Gils, Carla H Van ; Peeters, Petra H M ; Bueno-De-Mesquita, H. Bas ; Ros, Martine M. ; Lund, Eiliv ; Ardanaz, Eva ; Chirlaque, María Dolores ; Jakszyn, Paula ; Larrañaga, Nerea ; Losada, A. ; Martínez-García, Carmen ; Ågren, Åsa ; Hallmans, Göran ; Berglund, Göran ; Manjer, Jonas ; Allen, Naomi E. ; Key, Timothy J. ; Bingham, Sheila ; Khaw, Kay Tee ; Slimani, Nadia ; Ferrari, Pietro ; Boffetta, Paolo ; Norat, Teresa ; Vineis, Paolo ; Riboli, Elio. / Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). In: Cancer Causes and Control. 2007 ; Vol. 18, No. 5. pp. 537-549.
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abstract = "Introduction: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. Material and methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and subentities. Results: There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95, 95{\%} confidence interval (CI) 0.78-1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95{\%} CI 0.23-1.02). Conclusion: In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation.",
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T1 - Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Rohrmann, Sabine

AU - Becker, Nikolaus

AU - Linseisen, Jakob

AU - Nieters, Alexandra

AU - Rüdiger, Thomas

AU - Raaschou-Nielsen, Ole

AU - Tjønneland, Anne

AU - Johnsen, Hans E.

AU - Overvad, Kim

AU - Kaaks, Rudolf

AU - Bergmann, Manuela M.

AU - Boeing, Heiner

AU - Benetou, Vasiliki

AU - Psaltopoulou, Theodora

AU - Trichopoulou, Antonia

AU - Masala, Giovanna

AU - Mattiello, Amalia

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Gils, Carla H Van

AU - Peeters, Petra H M

AU - Bueno-De-Mesquita, H. Bas

AU - Ros, Martine M.

AU - Lund, Eiliv

AU - Ardanaz, Eva

AU - Chirlaque, María Dolores

AU - Jakszyn, Paula

AU - Larrañaga, Nerea

AU - Losada, A.

AU - Martínez-García, Carmen

AU - Ågren, Åsa

AU - Hallmans, Göran

AU - Berglund, Göran

AU - Manjer, Jonas

AU - Allen, Naomi E.

AU - Key, Timothy J.

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Slimani, Nadia

AU - Ferrari, Pietro

AU - Boffetta, Paolo

AU - Norat, Teresa

AU - Vineis, Paolo

AU - Riboli, Elio

PY - 2007/6

Y1 - 2007/6

N2 - Introduction: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. Material and methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and subentities. Results: There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95, 95% confidence interval (CI) 0.78-1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95% CI 0.23-1.02). Conclusion: In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation.

AB - Introduction: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. Material and methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and subentities. Results: There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95, 95% confidence interval (CI) 0.78-1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95% CI 0.23-1.02). Conclusion: In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation.

KW - Cohort study

KW - Fruits

KW - Hodgkin lymphoma

KW - Non-Hodgkin lymphoma

KW - Vegetables

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