Fruit and vegetable consumption and mortality

Max Leenders, Ivonne Sluijs, Martine M. Ros, Hendriek C. Boshuizen, Peter D. Siersema, Pietro Ferrari, Cornelia Weikert, Anne Tjønneland, Anja Olsen, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laura Nailler, Birgit Teucher, Kuanrong Li, Heiner Boeing, Manuela M. Bergmann, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico PalliValeria Pala, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Petra H M Peeters, Carla H. Van Gils, Eiliv Lund, Dagrun Engeset, Maria Luisa Redondo, Antonio Agudo, Maria José Sánchez, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Ulrika Ericson, Lena Maria Nilsson, Kay Tee Khaw, Nicholas J. Wareham, Timothy J. Key, Francesca L. Crowe, Isabelle Romieu, Marc J. Gunter, Valentina Gallo, Kim Overvad, Elio Riboli, H. Bas Bueno-De-Mesquita

Research output: Contribution to journalArticle

Abstract

In this study, the relation between fruit and vegetable consumption and mortality was investigated within the European Prospective Investigation Into Cancer and Nutrition. Survival analyses were performed, including 451,151 participants from 10 European countries, recruited between 1992 and 2000 and followed until 2010. Hazard ratios, rate advancement periods, and preventable proportions to respectively compare risk of death between quartiles of consumption, to estimate the period by which the risk of death was postponed among high consumers, and to estimate proportions of deaths that could be prevented if all participants would shift their consumption 1 quartile upward. Consumption of fruits and vegetables was inversely associated with all-cause mortality (for the highest quartile, hazard ratio = 0.90, 95% confidence interval (CI): 0.86, 0.94), with a rate advancement period of 1.12 years (95% CI: 0.70, 1.54), and with a preventable proportion of 2.95%. This association was driven mainly by cardiovascular disease mortality (for the highest quartile, hazard ratio = 0.85, 95% CI: 0.77, 0.93). Stronger inverse associations were observed for participants with high alcohol consumption or high body mass index and suggested in smokers. Inverse associations were stronger for raw than for cooked vegetable consumption. These results support the evidence that fruit and vegetable consumption is associated with a lower risk of death.

Original languageEnglish
Pages (from-to)590-602
Number of pages13
JournalAmerican Journal of Epidemiology
Volume178
Issue number4
DOIs
Publication statusPublished - Aug 15 2013

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Vegetables
Fruit
Mortality
Confidence Intervals
Survival Analysis
Alcohol Drinking
Body Mass Index
Cardiovascular Diseases
Neoplasms

Keywords

  • fruit
  • mortality
  • prospective studies
  • survival analysis
  • vegetables

ASJC Scopus subject areas

  • Epidemiology

Cite this

Leenders, M., Sluijs, I., Ros, M. M., Boshuizen, H. C., Siersema, P. D., Ferrari, P., ... Bas Bueno-De-Mesquita, H. (2013). Fruit and vegetable consumption and mortality. American Journal of Epidemiology, 178(4), 590-602. https://doi.org/10.1093/aje/kwt006

Fruit and vegetable consumption and mortality. / Leenders, Max; Sluijs, Ivonne; Ros, Martine M.; Boshuizen, Hendriek C.; Siersema, Peter D.; Ferrari, Pietro; Weikert, Cornelia; Tjønneland, Anne; Olsen, Anja; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Nailler, Laura; Teucher, Birgit; Li, Kuanrong; Boeing, Heiner; Bergmann, Manuela M.; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Peeters, Petra H M; Van Gils, Carla H.; Lund, Eiliv; Engeset, Dagrun; Redondo, Maria Luisa; Agudo, Antonio; Sánchez, Maria José; Navarro, Carmen; Ardanaz, Eva; Sonestedt, Emily; Ericson, Ulrika; Nilsson, Lena Maria; Khaw, Kay Tee; Wareham, Nicholas J.; Key, Timothy J.; Crowe, Francesca L.; Romieu, Isabelle; Gunter, Marc J.; Gallo, Valentina; Overvad, Kim; Riboli, Elio; Bas Bueno-De-Mesquita, H.

In: American Journal of Epidemiology, Vol. 178, No. 4, 15.08.2013, p. 590-602.

Research output: Contribution to journalArticle

Leenders, M, Sluijs, I, Ros, MM, Boshuizen, HC, Siersema, PD, Ferrari, P, Weikert, C, Tjønneland, A, Olsen, A, Boutron-Ruault, MC, Clavel-Chapelon, F, Nailler, L, Teucher, B, Li, K, Boeing, H, Bergmann, MM, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Pala, V, Panico, S, Tumino, R, Sacerdote, C, Peeters, PHM, Van Gils, CH, Lund, E, Engeset, D, Redondo, ML, Agudo, A, Sánchez, MJ, Navarro, C, Ardanaz, E, Sonestedt, E, Ericson, U, Nilsson, LM, Khaw, KT, Wareham, NJ, Key, TJ, Crowe, FL, Romieu, I, Gunter, MJ, Gallo, V, Overvad, K, Riboli, E & Bas Bueno-De-Mesquita, H 2013, 'Fruit and vegetable consumption and mortality', American Journal of Epidemiology, vol. 178, no. 4, pp. 590-602. https://doi.org/10.1093/aje/kwt006
Leenders M, Sluijs I, Ros MM, Boshuizen HC, Siersema PD, Ferrari P et al. Fruit and vegetable consumption and mortality. American Journal of Epidemiology. 2013 Aug 15;178(4):590-602. https://doi.org/10.1093/aje/kwt006
Leenders, Max ; Sluijs, Ivonne ; Ros, Martine M. ; Boshuizen, Hendriek C. ; Siersema, Peter D. ; Ferrari, Pietro ; Weikert, Cornelia ; Tjønneland, Anne ; Olsen, Anja ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Françoise ; Nailler, Laura ; Teucher, Birgit ; Li, Kuanrong ; Boeing, Heiner ; Bergmann, Manuela M. ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Palli, Domenico ; Pala, Valeria ; Panico, Salvatore ; Tumino, Rosario ; Sacerdote, Carlotta ; Peeters, Petra H M ; Van Gils, Carla H. ; Lund, Eiliv ; Engeset, Dagrun ; Redondo, Maria Luisa ; Agudo, Antonio ; Sánchez, Maria José ; Navarro, Carmen ; Ardanaz, Eva ; Sonestedt, Emily ; Ericson, Ulrika ; Nilsson, Lena Maria ; Khaw, Kay Tee ; Wareham, Nicholas J. ; Key, Timothy J. ; Crowe, Francesca L. ; Romieu, Isabelle ; Gunter, Marc J. ; Gallo, Valentina ; Overvad, Kim ; Riboli, Elio ; Bas Bueno-De-Mesquita, H. / Fruit and vegetable consumption and mortality. In: American Journal of Epidemiology. 2013 ; Vol. 178, No. 4. pp. 590-602.
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