Abstract
Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.
| Original language | English |
|---|---|
| Pages (from-to) | 2531-2535 |
| Number of pages | 5 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 14 |
| Issue number | 11 I |
| DOIs | |
| Publication status | Published - Nov 2005 |
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ASJC Scopus subject areas
- Epidemiology
- Oncology
Cite this
Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer : The European Prospective Investigation into Cancer and Nutrition. / Schulz, Mandy; Lahmann, Petra H.; Boeing, Heiner; Hoffmann, Kurt; Allen, Naomi; Key, Timothy J A; Bingham, Sheila; Wirfält, Elisabet; Berglund, Göran; Lundin, Eva; Hallmans, Göran; Lukanova, Annekatrin; Garcia, Carmen Martínez; González, Carlos A.; Tormo, Maria J.; Quirós, José R.; Ardanaz, Eva; Larrañaga, Nerea; Lund, Eiliv; Gram, Inger T.; Skeie, Guri; Peeters, Petra H M; Van Gils, Carla H.; Bas Bueno-De-Mesquita, H.; Büchner, Frederike L.; Pasanisi, Patrizia; Galasso, Rocco; Palli, Domenico; Tumino, Rosario; Vineis, Paolo; Trichopoulou, Antonia; Kalapothaki, Victoria; Trichopoulos, Dimitrios; Chang-Claude, Jenny; Linseisen, Jakob; Boutron-Ruault, Marie Christine; Touillaud, Marina; Clavel-Chapelon, Françoise; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Tetsche, Mette; Jenab, Mazda; Norat, Teresa; Kaaks, Rudolph; Riboli, Elio.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 14, No. 11 I, 11.2005, p. 2531-2535.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer
T2 - The European Prospective Investigation into Cancer and Nutrition
AU - Schulz, Mandy
AU - Lahmann, Petra H.
AU - Boeing, Heiner
AU - Hoffmann, Kurt
AU - Allen, Naomi
AU - Key, Timothy J A
AU - Bingham, Sheila
AU - Wirfält, Elisabet
AU - Berglund, Göran
AU - Lundin, Eva
AU - Hallmans, Göran
AU - Lukanova, Annekatrin
AU - Garcia, Carmen Martínez
AU - González, Carlos A.
AU - Tormo, Maria J.
AU - Quirós, José R.
AU - Ardanaz, Eva
AU - Larrañaga, Nerea
AU - Lund, Eiliv
AU - Gram, Inger T.
AU - Skeie, Guri
AU - Peeters, Petra H M
AU - Van Gils, Carla H.
AU - Bas Bueno-De-Mesquita, H.
AU - Büchner, Frederike L.
AU - Pasanisi, Patrizia
AU - Galasso, Rocco
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Trichopoulou, Antonia
AU - Kalapothaki, Victoria
AU - Trichopoulos, Dimitrios
AU - Chang-Claude, Jenny
AU - Linseisen, Jakob
AU - Boutron-Ruault, Marie Christine
AU - Touillaud, Marina
AU - Clavel-Chapelon, Françoise
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Tetsche, Mette
AU - Jenab, Mazda
AU - Norat, Teresa
AU - Kaaks, Rudolph
AU - Riboli, Elio
PY - 2005/11
Y1 - 2005/11
N2 - Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.
AB - Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.
UR - http://www.scopus.com/inward/record.url?scp=28644441431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28644441431&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-05-0159
DO - 10.1158/1055-9965.EPI-05-0159
M3 - Article
C2 - 16284374
AN - SCOPUS:28644441431
VL - 14
SP - 2531
EP - 2535
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 11 I
ER -