Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer: The European Prospective Investigation into Cancer and Nutrition

Mandy Schulz, Petra H. Lahmann, Heiner Boeing, Kurt Hoffmann, Naomi Allen, Timothy J A Key, Sheila Bingham, Elisabet Wirfält, Göran Berglund, Eva Lundin, Göran Hallmans, Annekatrin Lukanova, Carmen Martínez Garcia, Carlos A. González, Maria J. Tormo, José R. Quirós, Eva Ardanaz, Nerea Larrañaga, Eiliv Lund, Inger T. GramGuri Skeie, Petra H M Peeters, Carla H. Van Gils, H. Bas Bueno-De-Mesquita, Frederike L. Büchner, Patrizia Pasanisi, Rocco Galasso, Domenico Palli, Rosario Tumino, Paolo Vineis, Antonia Trichopoulou, Victoria Kalapothaki, Dimitrios Trichopoulos, Jenny Chang-Claude, Jakob Linseisen, Marie Christine Boutron-Ruault, Marina Touillaud, Françoise Clavel-Chapelon, Anja Olsen, Anne Tjønneland, Kim Overvad, Mette Tetsche, Mazda Jenab, Teresa Norat, Rudolph Kaaks, Elio Riboli

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.

Original languageEnglish
Pages (from-to)2531-2535
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume14
Issue number11 I
DOIs
Publication statusPublished - Nov 2005

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Vegetables
Fruit
Ovarian Neoplasms
Neoplasms
Garlic
Onions
Ovarian epithelial cancer
Brassica
Proportional Hazards Models
Incidence

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer : The European Prospective Investigation into Cancer and Nutrition. / Schulz, Mandy; Lahmann, Petra H.; Boeing, Heiner; Hoffmann, Kurt; Allen, Naomi; Key, Timothy J A; Bingham, Sheila; Wirfält, Elisabet; Berglund, Göran; Lundin, Eva; Hallmans, Göran; Lukanova, Annekatrin; Garcia, Carmen Martínez; González, Carlos A.; Tormo, Maria J.; Quirós, José R.; Ardanaz, Eva; Larrañaga, Nerea; Lund, Eiliv; Gram, Inger T.; Skeie, Guri; Peeters, Petra H M; Van Gils, Carla H.; Bas Bueno-De-Mesquita, H.; Büchner, Frederike L.; Pasanisi, Patrizia; Galasso, Rocco; Palli, Domenico; Tumino, Rosario; Vineis, Paolo; Trichopoulou, Antonia; Kalapothaki, Victoria; Trichopoulos, Dimitrios; Chang-Claude, Jenny; Linseisen, Jakob; Boutron-Ruault, Marie Christine; Touillaud, Marina; Clavel-Chapelon, Françoise; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Tetsche, Mette; Jenab, Mazda; Norat, Teresa; Kaaks, Rudolph; Riboli, Elio.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 14, No. 11 I, 11.2005, p. 2531-2535.

Research output: Contribution to journalArticle

Schulz, M, Lahmann, PH, Boeing, H, Hoffmann, K, Allen, N, Key, TJA, Bingham, S, Wirfält, E, Berglund, G, Lundin, E, Hallmans, G, Lukanova, A, Garcia, CM, González, CA, Tormo, MJ, Quirós, JR, Ardanaz, E, Larrañaga, N, Lund, E, Gram, IT, Skeie, G, Peeters, PHM, Van Gils, CH, Bas Bueno-De-Mesquita, H, Büchner, FL, Pasanisi, P, Galasso, R, Palli, D, Tumino, R, Vineis, P, Trichopoulou, A, Kalapothaki, V, Trichopoulos, D, Chang-Claude, J, Linseisen, J, Boutron-Ruault, MC, Touillaud, M, Clavel-Chapelon, F, Olsen, A, Tjønneland, A, Overvad, K, Tetsche, M, Jenab, M, Norat, T, Kaaks, R & Riboli, E 2005, 'Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer: The European Prospective Investigation into Cancer and Nutrition', Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 11 I, pp. 2531-2535. https://doi.org/10.1158/1055-9965.EPI-05-0159
Schulz, Mandy ; Lahmann, Petra H. ; Boeing, Heiner ; Hoffmann, Kurt ; Allen, Naomi ; Key, Timothy J A ; Bingham, Sheila ; Wirfält, Elisabet ; Berglund, Göran ; Lundin, Eva ; Hallmans, Göran ; Lukanova, Annekatrin ; Garcia, Carmen Martínez ; González, Carlos A. ; Tormo, Maria J. ; Quirós, José R. ; Ardanaz, Eva ; Larrañaga, Nerea ; Lund, Eiliv ; Gram, Inger T. ; Skeie, Guri ; Peeters, Petra H M ; Van Gils, Carla H. ; Bas Bueno-De-Mesquita, H. ; Büchner, Frederike L. ; Pasanisi, Patrizia ; Galasso, Rocco ; Palli, Domenico ; Tumino, Rosario ; Vineis, Paolo ; Trichopoulou, Antonia ; Kalapothaki, Victoria ; Trichopoulos, Dimitrios ; Chang-Claude, Jenny ; Linseisen, Jakob ; Boutron-Ruault, Marie Christine ; Touillaud, Marina ; Clavel-Chapelon, Françoise ; Olsen, Anja ; Tjønneland, Anne ; Overvad, Kim ; Tetsche, Mette ; Jenab, Mazda ; Norat, Teresa ; Kaaks, Rudolph ; Riboli, Elio. / Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer : The European Prospective Investigation into Cancer and Nutrition. In: Cancer Epidemiology Biomarkers and Prevention. 2005 ; Vol. 14, No. 11 I. pp. 2531-2535.
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abstract = "Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.",
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T1 - Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer

T2 - The European Prospective Investigation into Cancer and Nutrition

AU - Schulz, Mandy

AU - Lahmann, Petra H.

AU - Boeing, Heiner

AU - Hoffmann, Kurt

AU - Allen, Naomi

AU - Key, Timothy J A

AU - Bingham, Sheila

AU - Wirfält, Elisabet

AU - Berglund, Göran

AU - Lundin, Eva

AU - Hallmans, Göran

AU - Lukanova, Annekatrin

AU - Garcia, Carmen Martínez

AU - González, Carlos A.

AU - Tormo, Maria J.

AU - Quirós, José R.

AU - Ardanaz, Eva

AU - Larrañaga, Nerea

AU - Lund, Eiliv

AU - Gram, Inger T.

AU - Skeie, Guri

AU - Peeters, Petra H M

AU - Van Gils, Carla H.

AU - Bas Bueno-De-Mesquita, H.

AU - Büchner, Frederike L.

AU - Pasanisi, Patrizia

AU - Galasso, Rocco

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Trichopoulou, Antonia

AU - Kalapothaki, Victoria

AU - Trichopoulos, Dimitrios

AU - Chang-Claude, Jenny

AU - Linseisen, Jakob

AU - Boutron-Ruault, Marie Christine

AU - Touillaud, Marina

AU - Clavel-Chapelon, Françoise

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Tetsche, Mette

AU - Jenab, Mazda

AU - Norat, Teresa

AU - Kaaks, Rudolph

AU - Riboli, Elio

PY - 2005/11

Y1 - 2005/11

N2 - Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.

AB - Objective: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view. Methods: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done. Results: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk. Conclusion: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.

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