Fruit and vegetables consumption is directly associated to survival after prostate cancer

M. Taborelli, J. Polesel, M. Parpinel, C. Stocco, S. Birri, D. Serraino, A. Zucchetto

Research output: Contribution to journalArticlepeer-review


Scope: Since the evidence on the role of diet on prostate cancer (PCa) prognosis is still controversial, we evaluated the long-term effects of fruit and vegetables consumption on survival after PCa. Methods and results: A retrospective cohort study included 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy and followed up to 2013. A validated food frequency questionnaire assessed the usual diet in the 2 years before PCa diagnosis, including detailed fruit and vegetables consumption. Adjusted hazard ratios (HRs) of death with 95% confidence intervals (CIs) were estimated using Fine–Gray models. PCa patients with a consumption of both fruit and vegetables above the median showed a higher 15-year overall survival probability than those with lower intakes (71% versus 58%, p = 0.04; HR = 0.66, 95% CI: 0.47–0.93). Consumption of foods rich in fiber (HR = 0.59, 95% CI: 0.41–0.86) and proanthocyanidins (HR = 0.58, 95% CI: 0.40–0.82) were inversely associated with overall mortality. Interestingly, proanthocyanidins (HR = 0.52; 95% CI: 0.27–0.98) and flavonols (HR = 0.40; 95% CI: 0.19–0.84) were inversely associated also with PCa-specific mortality. Conclusion: High consumption of fruit and vegetables offers an advantage in survival among the rising number of men living after a PCa diagnosis, possibly through the epigenetic effect of some nutrients. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Original languageEnglish
JournalMolecular Nutrition and Food Research
Issue number4
Publication statusPublished - 2017


  • Fruit
  • Prostate cancer
  • Survival
  • Vegetables
  • aged
  • dietary fiber
  • feeding behavior
  • fruit
  • human
  • male
  • middle aged
  • physiology
  • prostate tumor
  • survival
  • vegetable
  • Aged
  • Dietary Fiber
  • Feeding Behavior
  • Humans
  • Male
  • Middle Aged
  • Prostatic Neoplasms


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