Fruits and vegetables and renal cell carcinoma: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Steffen Weikert, Heiner Boeing, Tobias Pischon, Anja Olsen, Anne Tjonneland, Kim Overvad, Nikolaus Becker, Jacob Linseisen, Petra H. Lahmann, Athina Arvaniti, Christina Kassapa, Antonia Trichoupoulou, Sabina Sieri, Domenico Palli, Rosario Tumino, Paolo Vineis, Salvatore Panico, Carla H. Van Gils, Petra H M Peeters, H. Bas Bueno-De-MesquitaFrederike L. Büchner, Börje Ljungberg, Göran Hallmans, Göran Berglund, Elisabet Wirfält, Guillem Pera, Miren Dorronsoro, Aurelio Barricarte Gurrea, Carmen Navarro, Carmen Martinez, J. Ramón Quirós, Naomi Allen, Andrew Roddam, Sheila Bingham, Mazda Jenab, Nadia Slimani, Teresa Norat, Elio Riboli

Research output: Contribution to journalArticlepeer-review


We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC were identified. The associations of consumption of total vegetables, total fruits, combined total fruits and vegetables and specific subtypes of vegetables with RCC risk were analyzed using Cox proportional hazards, stratified by centre and adjusted for potential confounders. No significant associations between fruit and vegetable consumption and RCC risk were observed despite a wide range of intake. The estimated relative risks (95% confidence intervals [CI]) in men and women combined were 0.97 (0.85-1.11) per 40 g increase in vegetable intake, 1.03 (0.97-1.08) per 40 g increase in fruit intake and 1.02 (0.93-1.11) per 80 g increase in fruit and vegetable intake combined. Among the vegetable subtypes, an inverse association was observed for root vegetables (RR per 8 g increase: 0.88; 95% CI: 0.78-0.99). These results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although we cannot exclude the possibility that very low consumption is related to higher risk. The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation.

Original languageEnglish
Pages (from-to)3133-3139
Number of pages7
JournalInternational Journal of Cancer
Issue number12
Publication statusPublished - Jun 15 2006


  • Cohort study
  • Epidemiology
  • Food
  • Incidence
  • Kidney cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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