FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women

Domenico Rendina, Fernando Gianfrancesco, Gianpaolo De Filippo, Daniela Merlotti, Teresa Esposito, Alessandra Mingione, Ranuccio Nuti, Pasquale Strazzullo, Giuseppe Mossetti, Luigi Gennari

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objective: FSH, via its receptor (FSHR), influences bone remodeling and osteoclast proliferation and activity. The aim of this study was to evaluate the influence of two single nucleotide polymorphisms (SNPs) of the FSHR gene on bone mineral density (BMD) and bone turnover markers (bone alkaline phosphatase and type I collagen C-telopeptides) in postmenopausal women. Methods: Two hundred and eighty-nine unrelated postmenopausal women were genotyped for the SNPs rs1394205 and rs6166. BMD was estimated using dual-energy X-ray absorptiometry and quantitative ultrasound (QUS) methodologies. Results: AA rs6166 women showed a lower BMD (femoral neck and total body), lower stiffness index (calcaneal QUS), and higher serum levels of bone turnover markers compared to GG rs6166 women. The prevalence of osteoporosis was significantly higher in AA rs6166 women compared with GG rs6166 women. These results were not influenced by circulating levels of FSH and estrogens. Conclusion: The SNP rs6166 of the FSHR gene significantly influences BMD in postmenopausal women. In particular, AA rs6166 women are at increased risk of postmenopausal osteoporosis compared with GG rs6166 women, independently of circulating levels of FSH and estrogens. Previous studies have demonstrated that this SNP influences cell and tissue response to hyperstimulation of FSHR in vivo and in vitro. Our study results appear in agreement with these experimental data and with known biological actions of FSH/FSHR system in bone homeostasis.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalEuropean Journal of Endocrinology
Volume163
Issue number1
DOIs
Publication statusPublished - Jul 1 2010

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Bone Remodeling
Bone Density
Bone and Bones
Genes
Single Nucleotide Polymorphism
Estrogens
Postmenopausal Osteoporosis
Femur Neck
Photon Absorptiometry
Osteoclasts
Collagen Type I
Osteoporosis
Alkaline Phosphatase
Homeostasis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Rendina, D., Gianfrancesco, F., De Filippo, G., Merlotti, D., Esposito, T., Mingione, A., ... Gennari, L. (2010). FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women. European Journal of Endocrinology, 163(1), 165-172. https://doi.org/10.1530/EJE-10-0043

FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women. / Rendina, Domenico; Gianfrancesco, Fernando; De Filippo, Gianpaolo; Merlotti, Daniela; Esposito, Teresa; Mingione, Alessandra; Nuti, Ranuccio; Strazzullo, Pasquale; Mossetti, Giuseppe; Gennari, Luigi.

In: European Journal of Endocrinology, Vol. 163, No. 1, 01.07.2010, p. 165-172.

Research output: Contribution to journalArticle

Rendina, D, Gianfrancesco, F, De Filippo, G, Merlotti, D, Esposito, T, Mingione, A, Nuti, R, Strazzullo, P, Mossetti, G & Gennari, L 2010, 'FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women', European Journal of Endocrinology, vol. 163, no. 1, pp. 165-172. https://doi.org/10.1530/EJE-10-0043
Rendina D, Gianfrancesco F, De Filippo G, Merlotti D, Esposito T, Mingione A et al. FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women. European Journal of Endocrinology. 2010 Jul 1;163(1):165-172. https://doi.org/10.1530/EJE-10-0043
Rendina, Domenico ; Gianfrancesco, Fernando ; De Filippo, Gianpaolo ; Merlotti, Daniela ; Esposito, Teresa ; Mingione, Alessandra ; Nuti, Ranuccio ; Strazzullo, Pasquale ; Mossetti, Giuseppe ; Gennari, Luigi. / FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women. In: European Journal of Endocrinology. 2010 ; Vol. 163, No. 1. pp. 165-172.
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