Abstract
The single nucleotide polymorphism p.N680S of the follicle-stimulating hormone (FSH) receptor (FSHR) is a discrete marker of ovarian response but previous in vitro studies failed to demonstrate differences in the response to FSH between N and S carrier cells. Here we demonstrate that p.N680S mediates different kinetics of the response to FSH in vitro. Intracellular cAMP production is faster in p.N680S N than in S homozygous human granulosa cells (45 versus 90. min to achieve the plateau, respectively; Mann-Whitney's U-test; p
Original language | English |
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Pages (from-to) | 83-91 |
Number of pages | 9 |
Journal | Molecular and Cellular Endocrinology |
Volume | 393 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Aug 5 2014 |
Keywords
- FSH
- FSHR
- Granulosa cells
- P.N680S
- Polymorphism
ASJC Scopus subject areas
- Endocrinology
- Molecular Biology
- Biochemistry
- Medicine(all)