FSHR polymorphism p.N680S mediates different responses to FSH in vitro

Livio Casarini; Valeria Moriondo; Marco Marino; Francesca Adversi; Francesco Capodanno; Chiarina Grisolia; Antonio La Marca; Giovanni Battista La Sala; Manuela Simoni

doi:10.1016/j.mce.2014.06.013

FSHR polymorphism p.N680S mediates different responses to FSH in vitro

Livio Casarini, Valeria Moriondo, Marco Marino, Francesca Adversi, Francesco Capodanno, Chiarina Grisolia, Antonio La Marca, Giovanni Battista La Sala, Manuela Simoni

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

The single nucleotide polymorphism p.N680S of the follicle-stimulating hormone (FSH) receptor (FSHR) is a discrete marker of ovarian response but previous in vitro studies failed to demonstrate differences in the response to FSH between N and S carrier cells. Here we demonstrate that p.N680S mediates different kinetics of the response to FSH in vitro. Intracellular cAMP production is faster in p.N680S N than in S homozygous human granulosa cells (45 versus 90. min to achieve the plateau, respectively; Mann-Whitney's U-test; p

Original language	English
Pages (from-to)	83-91
Number of pages	9
Journal	Molecular and Cellular Endocrinology
Volume	393
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2014.06.013
Publication status	Published - Aug 5 2014

Keywords

FSH
FSHR
Granulosa cells
P.N680S
Polymorphism

ASJC Scopus subject areas

Endocrinology
Molecular Biology
Biochemistry
Medicine(all)

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10.1016/j.mce.2014.06.013

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FSHR polymorphism p.N680S mediates different responses to FSH in vitro. / Casarini, Livio; Moriondo, Valeria; Marino, Marco; Adversi, Francesca; Capodanno, Francesco; Grisolia, Chiarina; La Marca, Antonio; La Sala, Giovanni Battista; Simoni, Manuela.

In: Molecular and Cellular Endocrinology, Vol. 393, No. 1-2, 05.08.2014, p. 83-91.

Research output: Contribution to journal › Article › peer-review

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title = "FSHR polymorphism p.N680S mediates different responses to FSH in vitro",

abstract = "The single nucleotide polymorphism p.N680S of the follicle-stimulating hormone (FSH) receptor (FSHR) is a discrete marker of ovarian response but previous in vitro studies failed to demonstrate differences in the response to FSH between N and S carrier cells. Here we demonstrate that p.N680S mediates different kinetics of the response to FSH in vitro. Intracellular cAMP production is faster in p.N680S N than in S homozygous human granulosa cells (45 versus 90. min to achieve the plateau, respectively; Mann-Whitney's U-test; p",

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author = "Livio Casarini and Valeria Moriondo and Marco Marino and Francesca Adversi and Francesco Capodanno and Chiarina Grisolia and {La Marca}, Antonio and {La Sala}, {Giovanni Battista} and Manuela Simoni",

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AU - Casarini, Livio

AU - Moriondo, Valeria

AU - Marino, Marco

AU - Adversi, Francesca

AU - Capodanno, Francesco

AU - Grisolia, Chiarina

AU - La Marca, Antonio

AU - La Sala, Giovanni Battista

AU - Simoni, Manuela

PY - 2014/8/5

Y1 - 2014/8/5

N2 - The single nucleotide polymorphism p.N680S of the follicle-stimulating hormone (FSH) receptor (FSHR) is a discrete marker of ovarian response but previous in vitro studies failed to demonstrate differences in the response to FSH between N and S carrier cells. Here we demonstrate that p.N680S mediates different kinetics of the response to FSH in vitro. Intracellular cAMP production is faster in p.N680S N than in S homozygous human granulosa cells (45 versus 90. min to achieve the plateau, respectively; Mann-Whitney's U-test; p

AB - The single nucleotide polymorphism p.N680S of the follicle-stimulating hormone (FSH) receptor (FSHR) is a discrete marker of ovarian response but previous in vitro studies failed to demonstrate differences in the response to FSH between N and S carrier cells. Here we demonstrate that p.N680S mediates different kinetics of the response to FSH in vitro. Intracellular cAMP production is faster in p.N680S N than in S homozygous human granulosa cells (45 versus 90. min to achieve the plateau, respectively; Mann-Whitney's U-test; p

KW - FSH

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KW - Granulosa cells

KW - P.N680S

KW - Polymorphism

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FSHR polymorphism p.N680S mediates different responses to FSH in vitro

Abstract

Keywords

ASJC Scopus subject areas

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