FSHR polymorphism p.N680S mediates different responses to FSH in vitro

Livio Casarini, Valeria Moriondo, Marco Marino, Francesca Adversi, Francesco Capodanno, Chiarina Grisolia, Antonio La Marca, Giovanni Battista La Sala, Manuela Simoni

Research output: Contribution to journalArticlepeer-review

Abstract

The single nucleotide polymorphism p.N680S of the follicle-stimulating hormone (FSH) receptor (FSHR) is a discrete marker of ovarian response but previous in vitro studies failed to demonstrate differences in the response to FSH between N and S carrier cells. Here we demonstrate that p.N680S mediates different kinetics of the response to FSH in vitro. Intracellular cAMP production is faster in p.N680S N than in S homozygous human granulosa cells (45 versus 90. min to achieve the plateau, respectively; Mann-Whitney's U-test; p

Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume393
Issue number1-2
DOIs
Publication statusPublished - Aug 5 2014

Keywords

  • FSH
  • FSHR
  • Granulosa cells
  • P.N680S
  • Polymorphism

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry
  • Medicine(all)

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