FT-IR study on solvent effects in building blocks of bioactive compounds. V

C. Conti, R. Galeazzi, E. Giorgini, G. Tosi

Research output: Contribution to journalArticlepeer-review

Abstract

3-Hydroxy-4-hydroxymethyl pyrrolidin-2-ones, easily prepared from the Baylis-Hillman adduct 1-ethyl-4-methyl-2-hydroxy-3-methylenebutanedioate, are useful intermediates in the synthesis of bioactive compounds. In order to understand the mechanism involved in this reaction, vibrational and Montecarlo molecular mechanics conformational analysis on 1-ethyl-4-methyl-2-hydroxy-3-methylenebutanedioate were carried out, confirming the existence of a low energy intramolecular H-bonded five-member ring.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalJournal of Molecular Structure
Volume790
Issue number1-3
DOIs
Publication statusPublished - Jun 5 2006

Keywords

  • Conformational analysis
  • Hydrogen bonding
  • Infrared spectroscopy
  • Solvent effects

ASJC Scopus subject areas

  • Structural Biology
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Atomic and Molecular Physics, and Optics
  • Materials Science (miscellaneous)

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