Ftorafur: A self-limiting source of 5-fluorouracil?

L. M. van Putten, P. Lelieveld, C. Pantarotto, M. Salmona, F. Spreafico

Research output: Contribution to journalArticlepeer-review


Studies of the cell killing effectiveness of ftorafur were carried out against 5-fluorouracil (5-FU). It appeared that in divided doses ftorafur is both relatively less toxic in terms of LD50 and bone marrow stem cell killing and less effective against L1210 and a mouse osteosarcoma than 5-FU. Pharmacokinetic analysis revealed that upon repeated administration of 5-FU there is an increase in late drug serum levels and a decreased clearance of 5-FU from the serum. Repeated administration of ftorafur is not associated with significant differences in serum levels of 5-FU or ftorafur. It is concluded that the relatively good tolerance to divided doses of ftorafur in comparison with divided doses of 5-FU may be a consequence of the pharmacokinetic differences.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalCancer Chemotherapy and Pharmacology
Issue number1
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology


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