Abstract
Recent studies have shown that structural abnormalities of chromosome 17 resulting in gain of material are the most frequent genetic changes in neuroblastoma. We have established a new neuroblastoma cell line from a patient whose disease had evolved from stage 4s to 4, without evidence of deletion of the short arm of chromosome 1 and MYCN amplification, which are considered the most typical genetic indicators of aggressive disease. The cytogenetic study allowed a full characterization of the chromosome changes, and revealed a complex translocation of chromosome 17 leading to a derivative marker which may be described as follows: der(11)t(11;17)(p15;q12)t(11;17)(q22;q12). This resulted in a gain of part of the long arms of chromosome 17, which was recently associated with poor prognosis. Copyright (C) 1999 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 124-132 |
| Number of pages | 9 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 116 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 15 2000 |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation. / Panarello, Claudio; Morerio, Cristina; Russo, Ivana; Pasquali, Francesco; Rapella, Annamaria; Corrias, Maria Valeria; Morando, Adriana; Rosanda, Cristina.
In: Cancer Genetics and Cytogenetics, Vol. 116, No. 2, 15.01.2000, p. 124-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation
AU - Panarello, Claudio
AU - Morerio, Cristina
AU - Russo, Ivana
AU - Pasquali, Francesco
AU - Rapella, Annamaria
AU - Corrias, Maria Valeria
AU - Morando, Adriana
AU - Rosanda, Cristina
PY - 2000/1/15
Y1 - 2000/1/15
N2 - Recent studies have shown that structural abnormalities of chromosome 17 resulting in gain of material are the most frequent genetic changes in neuroblastoma. We have established a new neuroblastoma cell line from a patient whose disease had evolved from stage 4s to 4, without evidence of deletion of the short arm of chromosome 1 and MYCN amplification, which are considered the most typical genetic indicators of aggressive disease. The cytogenetic study allowed a full characterization of the chromosome changes, and revealed a complex translocation of chromosome 17 leading to a derivative marker which may be described as follows: der(11)t(11;17)(p15;q12)t(11;17)(q22;q12). This resulted in a gain of part of the long arms of chromosome 17, which was recently associated with poor prognosis. Copyright (C) 1999 Elsevier Science Inc.
AB - Recent studies have shown that structural abnormalities of chromosome 17 resulting in gain of material are the most frequent genetic changes in neuroblastoma. We have established a new neuroblastoma cell line from a patient whose disease had evolved from stage 4s to 4, without evidence of deletion of the short arm of chromosome 1 and MYCN amplification, which are considered the most typical genetic indicators of aggressive disease. The cytogenetic study allowed a full characterization of the chromosome changes, and revealed a complex translocation of chromosome 17 leading to a derivative marker which may be described as follows: der(11)t(11;17)(p15;q12)t(11;17)(q22;q12). This resulted in a gain of part of the long arms of chromosome 17, which was recently associated with poor prognosis. Copyright (C) 1999 Elsevier Science Inc.
UR - http://www.scopus.com/inward/record.url?scp=0033992076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033992076&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(99)00140-5
DO - 10.1016/S0165-4608(99)00140-5
M3 - Article
C2 - 10640144
AN - SCOPUS:0033992076
VL - 116
SP - 124
EP - 132
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -