Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation

Claudio Panarello, Cristina Morerio, Ivana Russo, Francesco Pasquali, Annamaria Rapella, Maria Valeria Corrias, Adriana Morando, Cristina Rosanda

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies have shown that structural abnormalities of chromosome 17 resulting in gain of material are the most frequent genetic changes in neuroblastoma. We have established a new neuroblastoma cell line from a patient whose disease had evolved from stage 4s to 4, without evidence of deletion of the short arm of chromosome 1 and MYCN amplification, which are considered the most typical genetic indicators of aggressive disease. The cytogenetic study allowed a full characterization of the chromosome changes, and revealed a complex translocation of chromosome 17 leading to a derivative marker which may be described as follows: der(11)t(11;17)(p15;q12)t(11;17)(q22;q12). This resulted in a gain of part of the long arms of chromosome 17, which was recently associated with poor prognosis. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)124-132
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume116
Issue number2
DOIs
Publication statusPublished - Jan 15 2000

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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