Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation

Claudio Panarello, Cristina Morerio, Ivana Russo, Francesco Pasquali, Annamaria Rapella, Maria Valeria Corrias, Adriana Morando, Cristina Rosanda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Recent studies have shown that structural abnormalities of chromosome 17 resulting in gain of material are the most frequent genetic changes in neuroblastoma. We have established a new neuroblastoma cell line from a patient whose disease had evolved from stage 4s to 4, without evidence of deletion of the short arm of chromosome 1 and MYCN amplification, which are considered the most typical genetic indicators of aggressive disease. The cytogenetic study allowed a full characterization of the chromosome changes, and revealed a complex translocation of chromosome 17 leading to a derivative marker which may be described as follows: der(11)t(11;17)(p15;q12)t(11;17)(q22;q12). This resulted in a gain of part of the long arms of chromosome 17, which was recently associated with poor prognosis. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)124-132
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume116
Issue number2
DOIs
Publication statusPublished - Jan 15 2000

Fingerprint

Chromosomes, Human, Pair 17
Neuroblastoma
Cytogenetics
Cell Line
Chromosomes, Human, Pair 1
Chromosomes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation. / Panarello, Claudio; Morerio, Cristina; Russo, Ivana; Pasquali, Francesco; Rapella, Annamaria; Corrias, Maria Valeria; Morando, Adriana; Rosanda, Cristina.

In: Cancer Genetics and Cytogenetics, Vol. 116, No. 2, 15.01.2000, p. 124-132.

Research output: Contribution to journalArticle

Panarello, C, Morerio, C, Russo, I, Pasquali, F, Rapella, A, Corrias, MV, Morando, A & Rosanda, C 2000, 'Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation', Cancer Genetics and Cytogenetics, vol. 116, no. 2, pp. 124-132. https://doi.org/10.1016/S0165-4608(99)00140-5
Panarello, Claudio ; Morerio, Cristina ; Russo, Ivana ; Pasquali, Francesco ; Rapella, Annamaria ; Corrias, Maria Valeria ; Morando, Adriana ; Rosanda, Cristina. / Full cytogenetic characterization of a new neuroblastoma cell line with a complex 17q translocation. In: Cancer Genetics and Cytogenetics. 2000 ; Vol. 116, No. 2. pp. 124-132.
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