Full thickness eosinophilia in oesophageal leiomyomatosis and idiopathic eosinophilic oesophagitis. A common allergic inflammatory profile?

Andrew G. Nicholson, Dechun Li, Ugo Pastorino, Peter Goldstraw, Peter K. Jeffery

Research output: Contribution to journalArticle

Abstract

Oesophageal leiomyomatosis and idiopathic eosinophilic oesophagitis are both extremely rare. The former is a diffuse proliferation of smooth muscle in the muscularis propria, whilst the latter is an idiopathic inflammatory condition, thought to be associated with background atopy and characterized by an infiltrate of eosinophils throughout the full thickness of the oesophagus. However, two recent cases of oesophageal leiomyomatosis showed similar full thickness infiltration of the oesophageal wall by eosinophils and this inflammatory cell infiltrate was investigated in conjunction with one case of idiopathic eosinophilic oesophagitis. All three had a similar allergic profile characterized by CD45RO-positive pruned T-lymphocytes, EG2- positive (i.e., activated) eosinophils, and tryptase-positive mast cells, together with gene expression for interleukin 4. Previous descriptions of leiomyomatosis describe an association with systemic mastocytosis and urticaria and the possibility that there is a common underlying allergic component to both disorders is raised.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalJournal of Pathology
Volume183
Issue number2
DOIs
Publication statusPublished - Oct 1997

Fingerprint

Leiomyomatosis
Eosinophilic Esophagitis
Eosinophilia
Eosinophils
Systemic Mastocytosis
Tryptases
Urticaria
Interleukin-4
Esophagus
Smooth Muscle
T-Lymphocytes
Gene Expression

Keywords

  • Eosinophilia
  • Idiopathic eosinophilic oesophagitis
  • Oesophageal leiomyomatosis
  • Oesophagus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Full thickness eosinophilia in oesophageal leiomyomatosis and idiopathic eosinophilic oesophagitis. A common allergic inflammatory profile? / Nicholson, Andrew G.; Li, Dechun; Pastorino, Ugo; Goldstraw, Peter; Jeffery, Peter K.

In: Journal of Pathology, Vol. 183, No. 2, 10.1997, p. 233-236.

Research output: Contribution to journalArticle

Nicholson, Andrew G. ; Li, Dechun ; Pastorino, Ugo ; Goldstraw, Peter ; Jeffery, Peter K. / Full thickness eosinophilia in oesophageal leiomyomatosis and idiopathic eosinophilic oesophagitis. A common allergic inflammatory profile?. In: Journal of Pathology. 1997 ; Vol. 183, No. 2. pp. 233-236.
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