Functional analysis of HIV-specific cytotoxic T lymphocytes in antiviral-treated-and-naive patients: A preliminary report

D. Trabattoni, S. Fossati, M. Biasin, A. Boasso, G. Rizzardini, R. Maserati, Mario Clerici

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

HIV-specific CTL functions were analyzed in HIV-infected individuals who did or did not receive antiretroviral therapy (ART). Results showed that gp 160 (env)-stimulated perforin- and granzyme-expressing CTL, as well as perforin and granzyme-specific mRNA, were reduced in treated patients whereas TNFα was increased in ART-treated compared to naive individuals. Reduction of perforin and granzyme-expressing cells was not secondary to impaired IFNγ production. A defect of CTL is observed in ART-treated individuals; this defect is not dependent on impaired Th cell function. These results reinforce the need for immunomodulants to successfully approach therapy of HIV infection.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume16
Issue number1
Publication statusPublished - 2002

Fingerprint

cytotoxic T-lymphocytes
Cytotoxic T-Lymphocytes
Granzymes
Perforin
Antiviral Agents
HIV
therapeutics
HIV infections
Therapeutics
HIV Infections
cells
Messenger RNA

Keywords

  • CTL
  • Cytokines
  • Cytotoxicity
  • HIV
  • Perforin

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

Functional analysis of HIV-specific cytotoxic T lymphocytes in antiviral-treated-and-naive patients : A preliminary report. / Trabattoni, D.; Fossati, S.; Biasin, M.; Boasso, A.; Rizzardini, G.; Maserati, R.; Clerici, Mario.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 16, No. 1, 2002, p. 25-29.

Research output: Contribution to journalArticle

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