Functional analysis of HIV-specific cytotoxic T lymphocytes in antiviral-treated-and-naive patients: A preliminary report

D. Trabattoni, S. Fossati, M. Biasin, A. Boasso, G. Rizzardini, R. Maserati, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

HIV-specific CTL functions were analyzed in HIV-infected individuals who did or did not receive antiretroviral therapy (ART). Results showed that gp 160 (env)-stimulated perforin- and granzyme-expressing CTL, as well as perforin and granzyme-specific mRNA, were reduced in treated patients whereas TNFα was increased in ART-treated compared to naive individuals. Reduction of perforin and granzyme-expressing cells was not secondary to impaired IFNγ production. A defect of CTL is observed in ART-treated individuals; this defect is not dependent on impaired Th cell function. These results reinforce the need for immunomodulants to successfully approach therapy of HIV infection.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume16
Issue number1
Publication statusPublished - 2002

Keywords

  • CTL
  • Cytokines
  • Cytotoxicity
  • HIV
  • Perforin

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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