Functional anatomy of motor recovery after early brain damage

Giancarlo Zito, Donatella Mattia, Francesco Tomaiuolo, Massimiliano Oliveri, Alessandro Castriota-Scanderbeg, Carlo Caltagirone, Umberto Sabatini

Research output: Contribution to journalArticlepeer-review


Functional magnetic resonance imaging and transcranial magnetic stimulation were used to examine a 34 year-old right-handed patient, who, at the age of 6 years, had experienced sudden right hemiplegia, seizures, and stupor during a bout of measles encephalitis, followed by incomplete distal right motor recovery. Morphological MRI showed massive unilateral enlargement of the left ventricle, associated with extreme thinning of the white and gray matter, with partial preservation of the pyramidal tract. Functional MRI and transcranial magnetic stimulation revealed reorganization of the motor cortices, and integrity of the corticospinal pathway, respectively. Our findings indicate that complete hand motor recovery may require functional connections between the motor cortical areas and cortical-subcortical structures, in addition to the retained integrity of the primary sensorimotor area and pyramidal tract.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
Issue number3
Publication statusPublished - Jun 2004

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Psychology(all)


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