TY - JOUR
T1 - Functional anatomy of motor recovery after early brain damage
AU - Zito, Giancarlo
AU - Mattia, Donatella
AU - Tomaiuolo, Francesco
AU - Oliveri, Massimiliano
AU - Castriota-Scanderbeg, Alessandro
AU - Caltagirone, Carlo
AU - Sabatini, Umberto
PY - 2004/6
Y1 - 2004/6
N2 - Functional magnetic resonance imaging and transcranial magnetic stimulation were used to examine a 34 year-old right-handed patient, who, at the age of 6 years, had experienced sudden right hemiplegia, seizures, and stupor during a bout of measles encephalitis, followed by incomplete distal right motor recovery. Morphological MRI showed massive unilateral enlargement of the left ventricle, associated with extreme thinning of the white and gray matter, with partial preservation of the pyramidal tract. Functional MRI and transcranial magnetic stimulation revealed reorganization of the motor cortices, and integrity of the corticospinal pathway, respectively. Our findings indicate that complete hand motor recovery may require functional connections between the motor cortical areas and cortical-subcortical structures, in addition to the retained integrity of the primary sensorimotor area and pyramidal tract.
AB - Functional magnetic resonance imaging and transcranial magnetic stimulation were used to examine a 34 year-old right-handed patient, who, at the age of 6 years, had experienced sudden right hemiplegia, seizures, and stupor during a bout of measles encephalitis, followed by incomplete distal right motor recovery. Morphological MRI showed massive unilateral enlargement of the left ventricle, associated with extreme thinning of the white and gray matter, with partial preservation of the pyramidal tract. Functional MRI and transcranial magnetic stimulation revealed reorganization of the motor cortices, and integrity of the corticospinal pathway, respectively. Our findings indicate that complete hand motor recovery may require functional connections between the motor cortical areas and cortical-subcortical structures, in addition to the retained integrity of the primary sensorimotor area and pyramidal tract.
UR - http://www.scopus.com/inward/record.url?scp=7244236517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7244236517&partnerID=8YFLogxK
U2 - 10.1080/13554790490495212
DO - 10.1080/13554790490495212
M3 - Article
C2 - 15788263
AN - SCOPUS:7244236517
VL - 10
SP - 265
EP - 269
JO - Neurocase
JF - Neurocase
SN - 1355-4794
IS - 3
ER -