Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone.

M. Grano, S. Colucci, A. Portoghese, G. Zambonin, R. Barattolo, M. Serra, K. Scotlandi, A. Teti, A. Zambonin Zallone

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cells harvested from human giant cell tumours of bone were characterized on the basis of morphological features, proliferative capacity, total(AP) and tartrate resistant acid phosphatase (TRAP) activity, and hormonal response. Culture were formed by mononucleated and multinucleated cells. Mononucleated cells showed fibroblastic morphology, whereas multinucleated cells showed osteoclastic phenotype. We conclude that in these cultures mature osteoclasts and their mononuclear precursors are present.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume68
Issue number4
Publication statusPublished - Apr 1992

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Giant Cell Tumor of Bone
Osteoclasts
Phenotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Grano, M., Colucci, S., Portoghese, A., Zambonin, G., Barattolo, R., Serra, M., ... Zambonin Zallone, A. (1992). Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone. Bollettino della Societa Italiana di Biologia Sperimentale, 68(4), 249-253.

Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone. / Grano, M.; Colucci, S.; Portoghese, A.; Zambonin, G.; Barattolo, R.; Serra, M.; Scotlandi, K.; Teti, A.; Zambonin Zallone, A.

In: Bollettino della Societa Italiana di Biologia Sperimentale, Vol. 68, No. 4, 04.1992, p. 249-253.

Research output: Contribution to journalArticle

Grano, M, Colucci, S, Portoghese, A, Zambonin, G, Barattolo, R, Serra, M, Scotlandi, K, Teti, A & Zambonin Zallone, A 1992, 'Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone.', Bollettino della Societa Italiana di Biologia Sperimentale, vol. 68, no. 4, pp. 249-253.
Grano, M. ; Colucci, S. ; Portoghese, A. ; Zambonin, G. ; Barattolo, R. ; Serra, M. ; Scotlandi, K. ; Teti, A. ; Zambonin Zallone, A. / Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone. In: Bollettino della Societa Italiana di Biologia Sperimentale. 1992 ; Vol. 68, No. 4. pp. 249-253.
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