Functional and clinical changes in upper limb spastic patients treated with botulinum toxin (BTX)

M. Panizza, M. Castagna, A. Di Summa, L. Saibene, G. Grioni, J. Nilsson

Research output: Contribution to journalArticle

Abstract

Spasticity is a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes (muscle tone) with exaggerated tendon jerks. In order to study the usefulness of botulinum toxin type A (BTX) as a therapy for spasticity, we studied 15 patients affected by spasticity secondary to stroke. Tests included: clinical evaluation of tone (Ashworth scale); active angles of extension and flexion at elbow and wrist; Hmax/Mmax ratio from flexor carpi radialis (FCR); H-reflex presynaptic inhibition from FCR during vibration; Task score; and video recording. Patients were injected with BTX into one or more muscles with total doses not exceeding 200 International Units (IU). The tests were performed immediately prior to injection and repeated 2 weeks afterwards. Furthermore, in eight patients, testing was also performed one month after BTX injection. Between two weeks and one month after BTX there were no statistically significant differences. A statistically significant difference in the Task and Ashworth scores before and after treatment emerged (p

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalFunctional Neurology
Volume15
Issue number3
Publication statusPublished - 2000

Keywords

  • Ashworth
  • Botulinum toxin
  • Spasticity
  • Task score
  • Upper limb

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Panizza, M., Castagna, M., Di Summa, A., Saibene, L., Grioni, G., & Nilsson, J. (2000). Functional and clinical changes in upper limb spastic patients treated with botulinum toxin (BTX). Functional Neurology, 15(3), 147-155.