TY - JOUR
T1 - Functional and molecular characterization by the CB04 monoclonal antibody of a cell surface structure exerting C3-complement receptor activity
AU - Malavasi, F.
AU - Funaro, A.
AU - Bellone, G.
AU - Caligaris-Cappio, F.
AU - Berti, E.
AU - Tetta, C.
AU - Dellabona, P.
AU - DeMaria, S.
AU - Campogrande, M.
AU - Cappa, A. P M
PY - 1985/11
Y1 - 1985/11
N2 - CB04 monoclonal antibody which reacts with an epitope of a surface molecule expressed on human monocytes has been elicited using peripheral blood lymphocytes as immunizer. The characterization of the monoclonal antibody examined at the phenotypic, molecular, and functional levels indicates that the CB04 antibody defines a structure present on monocytes, tissue macrophages, B cells, polymorphonucleates, and erythrocytes. The molecular weight (220 kD), the tissue distribution in health and disease conditions, and the involvement in relevant biological processes indicate that the CB04 structure is the receptor for the C3b fragment of the complement. The binding of the antibody to the cell surface induces inhibition of the C3bi receptorial function.
AB - CB04 monoclonal antibody which reacts with an epitope of a surface molecule expressed on human monocytes has been elicited using peripheral blood lymphocytes as immunizer. The characterization of the monoclonal antibody examined at the phenotypic, molecular, and functional levels indicates that the CB04 antibody defines a structure present on monocytes, tissue macrophages, B cells, polymorphonucleates, and erythrocytes. The molecular weight (220 kD), the tissue distribution in health and disease conditions, and the involvement in relevant biological processes indicate that the CB04 structure is the receptor for the C3b fragment of the complement. The binding of the antibody to the cell surface induces inhibition of the C3bi receptorial function.
KW - Complement receptor
KW - monoclonal antibody
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U2 - 10.1007/BF00915339
DO - 10.1007/BF00915339
M3 - Article
C2 - 2418053
AN - SCOPUS:0022393354
VL - 5
SP - 412
EP - 420
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
SN - 0271-9142
IS - 6
ER -