Functional and molecular insights into KSRP function in mRNA decay

Paola Briata; Ching Yi Chen; Andres Ramos; Roberto Gherzi

doi:10.1016/j.bbagrm.2012.11.003

Functional and molecular insights into KSRP function in mRNA decay

Paola Briata, Ching Yi Chen, Andres Ramos, Roberto Gherzi

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

KSRP is a single strand nucleic acid binding protein that controls gene expression at multiple levels. In this review we focus on the recent molecular, cellular, and structural insights into the mRNA decay promoting function of KSRP. We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms.

Original language	English
Pages (from-to)	689-694
Number of pages	6
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1829
Issue number	6-7
DOIs	https://doi.org/10.1016/j.bbagrm.2012.11.003
Publication status	Published - Jun 2013

Keywords

Extracellular signal
KH domain
MicroRNA maturation
MRNA decay

ASJC Scopus subject areas

Biochemistry
Biophysics
Genetics
Molecular Biology
Structural Biology

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10.1016/j.bbagrm.2012.11.003

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AU - Chen, Ching Yi

AU - Ramos, Andres

AU - Gherzi, Roberto

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AB - KSRP is a single strand nucleic acid binding protein that controls gene expression at multiple levels. In this review we focus on the recent molecular, cellular, and structural insights into the mRNA decay promoting function of KSRP. We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms.

KW - Extracellular signal

KW - KH domain

KW - MicroRNA maturation

KW - MRNA decay

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Functional and molecular insights into KSRP function in mRNA decay

Abstract

Keywords

ASJC Scopus subject areas

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