Abstract
KSRP is a single strand nucleic acid binding protein that controls gene expression at multiple levels. In this review we focus on the recent molecular, cellular, and structural insights into the mRNA decay promoting function of KSRP. We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 689-694 |
| Number of pages | 6 |
| Journal | Biochimica et Biophysica Acta - Gene Regulatory Mechanisms |
| Volume | 1829 |
| Issue number | 6-7 |
| DOIs | |
| Publication status | Published - Jun 2013 |
Keywords
- Extracellular signal
- KH domain
- MicroRNA maturation
- MRNA decay
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Genetics
- Molecular Biology
- Structural Biology
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Cite this
Briata, P., Chen, C. Y., Ramos, A., & Gherzi, R. (2013). Functional and molecular insights into KSRP function in mRNA decay. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1829(6-7), 689-694. https://doi.org/10.1016/j.bbagrm.2012.11.003