Functional and molecular insights into KSRP function in mRNA decay

Paola Briata, Ching Yi Chen, Andres Ramos, Roberto Gherzi

Research output: Contribution to journalArticle

Abstract

KSRP is a single strand nucleic acid binding protein that controls gene expression at multiple levels. In this review we focus on the recent molecular, cellular, and structural insights into the mRNA decay promoting function of KSRP. We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms.

Original languageEnglish
Pages (from-to)689-694
Number of pages6
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1829
Issue number6-7
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Extracellular signal
  • KH domain
  • MicroRNA maturation
  • MRNA decay

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Molecular Biology
  • Structural Biology

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