Functional and structural features of adipokine family

R. Raucci, F. Rusolo, A. Sharma, G. Colonna, G. Castello, S. Costantini

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

In the mid-1990s, the interest in adipose tissue was revived by the discovery of leptin. Since then numerous other hormones have been isolated from white adipose tissue that has no longer considered an inert tissue mainly devoted to energy storage but emerged as an active participant in regulating physiologic and pathologic processes, including immunity and inflammation. Adipose tissue produces and releases a variety of proinflammatory and anti-inflammatory factors, including the adipokines, as well as cytokines and chemokines. Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. In contrast, reduced leptin levels might predispose to increased susceptibility to infection caused by reduced T-cell responses in malnourished individuals. Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified. In this paper we want to review: (i) the role of adipose tissue in different biological processes, (ii) the functional and structural description of all the known adipokines subdivided in different subfamilies, (iii) the adipokine involvement in obesity and cancers, and (iv) the adipokine interactome.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalCytokine
Volume61
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Adipokines
Tissue
Adipose Tissue
Leptin
Obesity
Biological Phenomena
White Adipose Tissue
Pathologic Processes
Chemokines
T-cells
Insulin Resistance
Immunity
Anti-Inflammatory Agents
Cardiovascular Diseases
Energy storage
Hormones
Cytokines
Inflammation
T-Lymphocytes
Insulin

Keywords

  • Adipokines
  • Cancer
  • Obesity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Raucci, R., Rusolo, F., Sharma, A., Colonna, G., Castello, G., & Costantini, S. (2013). Functional and structural features of adipokine family. Cytokine, 61(1), 1-14. https://doi.org/10.1016/j.cyto.2012.08.036

Functional and structural features of adipokine family. / Raucci, R.; Rusolo, F.; Sharma, A.; Colonna, G.; Castello, G.; Costantini, S.

In: Cytokine, Vol. 61, No. 1, 01.2013, p. 1-14.

Research output: Contribution to journalArticle

Raucci, R, Rusolo, F, Sharma, A, Colonna, G, Castello, G & Costantini, S 2013, 'Functional and structural features of adipokine family', Cytokine, vol. 61, no. 1, pp. 1-14. https://doi.org/10.1016/j.cyto.2012.08.036
Raucci R, Rusolo F, Sharma A, Colonna G, Castello G, Costantini S. Functional and structural features of adipokine family. Cytokine. 2013 Jan;61(1):1-14. https://doi.org/10.1016/j.cyto.2012.08.036
Raucci, R. ; Rusolo, F. ; Sharma, A. ; Colonna, G. ; Castello, G. ; Costantini, S. / Functional and structural features of adipokine family. In: Cytokine. 2013 ; Vol. 61, No. 1. pp. 1-14.
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