Functional assessment of a skin care system in patients on chemotherapy

J. W. Fluhr, M. Miteva, G. Primavera, M. Ziemer, P. Elsner, E. Berardesca

Research output: Contribution to journalArticlepeer-review


Background/Purpose: Cancer patients undergoing chemotherapy frequently experience skin problems such as xerosis. The aim of this study was to verify whether a concomitant treatment with an acidic washing and an acidic emollient (both pH 5.5) can significantly improve the quality of the skin in such patients. Methods: 30 adult patients on chemotherapy experiencing dry and sensitive skin were included in a controlled, monocentric, 3-week treatment trial. One forearm served as a test site, the other one remained untreated. Noninvasive biophysical measurements were performed at baseline, on days 7, 14 and 21, along with clinical evaluation of the skin symptoms. Results: After a 3-week treatment, a significant increase in stratum corneum hydration was recorded in the treated site (p <0.001). Reduced transepidermal water loss values, consistent with a restored barrier function, were obtained (p <0.001). Casual sebum levels as measured by sebumetry showed a significant increase (p <0.03). All skin symptoms investigated revealed a considerable improvement over 3 weeks. Conclusion: Controlled and regular use of a skin care system, especially an acidic one, improved skin physiology in patients undergoing chemotherapy.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalSkin Pharmacology and Physiology
Issue number5
Publication statusPublished - Aug 2007


  • Antidry emulsion
  • Antidry lotion
  • Cancer
  • Chemotherapy
  • Dry skin
  • Skin care system
  • Skin toxicity

ASJC Scopus subject areas

  • Pharmacology
  • Physiology
  • Dermatology


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