Functional changes in coronary microcirculation after valve replacement in patients with aortic stenosis

Kim Rajappan, Ornella E. Rimoldi, Paolo G. Camici, Nicholas G. Bellenger, Dudley J. Pennell, Desmond J. Sheridan

Research output: Contribution to journalArticle

Abstract

Background - Increased extravascular compression and reduced diastolic perfusion time (DPT), rather than vascular remodeling, influence coronary microcirculatory dysfunction in aortic stenosis (AS). However, alterations after aortic valve replacement (AVR) remain unclear. The aim of the present study was to quantify changes in transmural perfusion and coronary vasodilator reserve (CVR), a measure of microcirculatory function, after AVR and determine the relative contribution of left ventricular mass (LVM) regression, change in aortic valve area (AVA), and DPT. Methods and Results - Twenty-two patients with AS were studied before and 1 year after AVR using echocardiography to measure AVA, cardiovascular magnetic resonance to assess LVM, and positron emission tomography to quantify resting and hyperemic myocardial blood flow (MBF) and CVR. Regression of LVM occurred in all patients (from 129±30 to 94±24 g/m 2; P

Original languageEnglish
Pages (from-to)3170-3175
Number of pages6
JournalCirculation
Volume107
Issue number25
DOIs
Publication statusPublished - Jul 1 2003

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Keywords

  • Hypertrophy
  • Microcirculation
  • Regression
  • Surgery
  • Valves

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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