Functional changes of brainstem reflexes in Parkinson's disease Conditioning of the blink reflex R2 component by paired and index finger stimulation

A. Lozza, J. L. Pepin, G. Rapisarda, A. Moglia, P. J. Delwaide

Research output: Contribution to journalArticle

Abstract

Recovery curves of the R2 component of the blink reflex have been studied in 10 control subjects and 13 parkinsonian patients both after ipsilateral paired stimulation of the supraorbital nerve and after index finger stimulation. In control subjects, both types of conditioning induced a comparable marked inhibition lasting more than 600 ms. In parkinsonian patients, inhibition was reduced after both conditionings. However, differences appeared in the magnitude of the changes: after paired stimulation, it was less significant (ANOVA and post-hoc Duncan's test: p = 0.04) than after index finger stimulation (p = 0.002). In that latter situation, the more marked reduction in inhibition is interpreted, in the light of current physiologic knowledge, by hypoactivity of the Nucleus Reticularis Giganto Cellularis (NRGC) which would make less efficient inhibitory interneurones in the trigemino-facial pathway. The results are thus compatible with the suggestion that NRGC is made indirectly less active in Parkinson's disease.

Original languageEnglish
Pages (from-to)679-687
Number of pages9
JournalJournal of Neural Transmission
Volume104
Issue number6-7
DOIs
Publication statusPublished - 1997

Fingerprint

Blinking
Fingers
Brain Stem
Parkinson Disease
Reflex
Interneurons
Analysis of Variance
Conditioning (Psychology)
Inhibition (Psychology)

Keywords

  • Blink reflex
  • Parkinson's disease
  • Pathophysiology
  • Recovery curves

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Functional changes of brainstem reflexes in Parkinson's disease Conditioning of the blink reflex R2 component by paired and index finger stimulation. / Lozza, A.; Pepin, J. L.; Rapisarda, G.; Moglia, A.; Delwaide, P. J.

In: Journal of Neural Transmission, Vol. 104, No. 6-7, 1997, p. 679-687.

Research output: Contribution to journalArticle

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N2 - Recovery curves of the R2 component of the blink reflex have been studied in 10 control subjects and 13 parkinsonian patients both after ipsilateral paired stimulation of the supraorbital nerve and after index finger stimulation. In control subjects, both types of conditioning induced a comparable marked inhibition lasting more than 600 ms. In parkinsonian patients, inhibition was reduced after both conditionings. However, differences appeared in the magnitude of the changes: after paired stimulation, it was less significant (ANOVA and post-hoc Duncan's test: p = 0.04) than after index finger stimulation (p = 0.002). In that latter situation, the more marked reduction in inhibition is interpreted, in the light of current physiologic knowledge, by hypoactivity of the Nucleus Reticularis Giganto Cellularis (NRGC) which would make less efficient inhibitory interneurones in the trigemino-facial pathway. The results are thus compatible with the suggestion that NRGC is made indirectly less active in Parkinson's disease.

AB - Recovery curves of the R2 component of the blink reflex have been studied in 10 control subjects and 13 parkinsonian patients both after ipsilateral paired stimulation of the supraorbital nerve and after index finger stimulation. In control subjects, both types of conditioning induced a comparable marked inhibition lasting more than 600 ms. In parkinsonian patients, inhibition was reduced after both conditionings. However, differences appeared in the magnitude of the changes: after paired stimulation, it was less significant (ANOVA and post-hoc Duncan's test: p = 0.04) than after index finger stimulation (p = 0.002). In that latter situation, the more marked reduction in inhibition is interpreted, in the light of current physiologic knowledge, by hypoactivity of the Nucleus Reticularis Giganto Cellularis (NRGC) which would make less efficient inhibitory interneurones in the trigemino-facial pathway. The results are thus compatible with the suggestion that NRGC is made indirectly less active in Parkinson's disease.

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