Functional characterization of brain tumors: An overview of the potential clinical value

Arturo Brunetti, Bruno Alfano, Andrea Soricelli, Enrico Tedeschi, Ciro Mainolfi, Eugenio M. Covelli, Luigi Aloj, Maria Rosaria Panico, Lucio Bazzicalupo, Marco Salvatore

Research output: Contribution to journalArticlepeer-review


Early detection and characterization are still challenging issues in the diagnostic approach to brain tumors. Among functional imaging techniques, a clinical role for positron emission tomography studies with [18F]-fluorodeoxyglucose and for single photon emission computed tomography studies with [201Tl]thallium-chloride has emerged. The clinical role of magnetic resonance spectroscopy is still being defined, whereas functional magnetic resonance imaging seems able to provide useful data for presurgical localization of critical cortical areas. Integration of morphostructural information provided by computed tomography and magnetic resonance imaging, with functional characterization and cyto-histologic evaluation of biologic markers, may assist in answering the open diagnostic questions concerning brain tumors.

Original languageEnglish
Pages (from-to)699-715
Number of pages17
JournalNuclear Medicine and Biology
Issue number6
Publication statusPublished - Aug 1996


  • brain tumors
  • emission computed tomography
  • functional imaging
  • functional MRI
  • magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging


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