Functional characterization of human thyroid tissue with immunohistochemistry

Antongiulio Faggiano, Bernard Caillou, Ludovic Lacroix, Monique Talbot, Sebastiano Filetti, Jean Michel Bidart, Martin Schlumberger

Research output: Contribution to journalArticlepeer-review

Abstract

Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases. In hyperfunctional thyroid tissues, staining for sodium/iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), and thyroglobulin (Tg) is increased. In hypofunctioning thyroid tissues, NIS staining is markedly decreased; in benign hypofunctioning adenomas, the expression of the other functional proteins is unmodified or slightly decreased, whereas their expression is profoundly decreased or absent in differentiated thyroid carcinoma.

Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalThyroid
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Endocrinology

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