Functional characterization of specific IgE antibodies for tetanus toxoid

Antonio Miadonna, Alberto Tedeschi, Ennio Leggieri, Marco Froldi, Carlo Zanussi

Research output: Contribution to journalArticle

Abstract

The specific IgE response that appears in subjects immunized with tetanus toxoid does not induce hypersensitivity reactions at subsequent immunizations. The type I immune response, therefore, was studied both in vivo and in vitro, in 11 subjects who had specific IgE antibodies for tetanus toxoid. The results showed that: 1. the specific IgE antibodies are heterogeneous regarding their affinity for the mast cell and basophil receptors; 2. the specific IgG antibodies for tetanus toxoid, at serum concentrations, are not able to interfere with the in vitro specific basophil degranulation; 3. in the PEG precipitare there are aggregates of specific IgE antibodies for tetanus toxoid. In vitro, these molecular aggregates are not able to sensitize the basophil cells.

Original languageEnglish
Pages (from-to)235-245
Number of pages11
JournalLa Ricerca in Clinica e in Laboratorio
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 1983

Keywords

  • Basophil receptors
  • IgE affinity
  • IgE aggregates
  • Tetanus toxoid

ASJC Scopus subject areas

  • Clinical Biochemistry

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