Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

Research output: Contribution to journalArticlepeer-review

Abstract

The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.

Original languageEnglish
Pages (from-to)460-463
Number of pages4
JournalNeuropharmacology
Volume40
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • Cholinergic interneurons
  • Electrophysiology
  • Metabotropic glutamate receptor
  • mGluRs
  • Striatum

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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