Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

A. Pisani; P. Bonsi; D. Centonze; G. Bernardi; P. Calabresi

doi:10.1016/S0028-3908(00)00184-2

Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

A. Pisani, P. Bonsi, D. Centonze, G. Bernardi, P. Calabresi

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.

Original language	English
Pages (from-to)	460-463
Number of pages	4
Journal	Neuropharmacology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/S0028-3908(00)00184-2
Publication status	Published - 2001

Keywords

Cholinergic interneurons
Electrophysiology
Metabotropic glutamate receptor
mGluRs
Striatum

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Drug Discovery
Pharmacology

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10.1016/S0028-3908(00)00184-2

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abstract = "The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.",

keywords = "Cholinergic interneurons, Electrophysiology, Metabotropic glutamate receptor, mGluRs, Striatum",

author = "A. Pisani and P. Bonsi and D. Centonze and G. Bernardi and P. Calabresi",

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AU - Pisani, A.

AU - Bonsi, P.

AU - Centonze, D.

AU - Bernardi, G.

AU - Calabresi, P.

PY - 2001

Y1 - 2001

N2 - The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.

AB - The group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane depolarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons.

KW - Cholinergic interneurons

KW - Electrophysiology

KW - Metabotropic glutamate receptor

KW - mGluRs

KW - Striatum

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Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

Abstract

Keywords

ASJC Scopus subject areas

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