Functional consequences and intracoronary localization of alpha-adrenergic stimulation of the canine coronary circulation

M. F. Maturi, R. Greene, B. Donohue, L. M. Dorsey, S. L. Bacharach, D. Vitale, R. E. Patterson

Research output: Contribution to journalArticle

Abstract

Although alpha-adrenergic stimulation can increase coronary vascular resistance, it remains unknown whether the vasoconstriction can override intrinsic coronary regulatory influences to produce ischemia. Methoxamine, 2 to 4 mg, was infused into the circumflex coronary artery of 23 chloralose-anesthetized open chest dogs, and resulted in a 68% increase in coronary vascular resistance. The functional consequence of this increased coronary vascular resistance was assessed by gated radionuclide ventriculography and ST-T wave changes on the electrocardiogram. In six dogs (Group I), aortic pressure changed trivially (

Original languageEnglish
Pages (from-to)885-893
Number of pages9
JournalJournal of the American College of Cardiology
Volume8
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Nursing(all)

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    Maturi, M. F., Greene, R., Donohue, B., Dorsey, L. M., Bacharach, S. L., Vitale, D., & Patterson, R. E. (1986). Functional consequences and intracoronary localization of alpha-adrenergic stimulation of the canine coronary circulation. Journal of the American College of Cardiology, 8(4), 885-893.