Functional correlates of t-Tau, p-Tau and Aβ1-42 amyloid cerebrospinal fluid levels in Alzheimer's disease

A 18F-FDG PET/CT study

Agostino Chiaravalloti, Alessandro Martorana, Giacomo Koch, Sofia Toniolo, Daniele Di Biagio, Barbara Di Pietro, Orazio Schillaci

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aim: The aim of the study was to investigate the relationships between cerebrospinal fluid (CSF) levels of t-Tau, p-Tau and amyloid-β (Aβ1-42) amyloid peptide and fluorine-18 fluorodeoxyglucose (18F-FDG) brain distribution in a group of patients with Alzheimer's disease. Materials and methods: The study included 81 newly diagnosed Alzheimer's disease patients according to the NINCDS-ADRDA criteria. The mean (± SD) age of the patients was 70 (± 6) years; 44 were male and 37 were female. All patients underwent a CSF assay and MRI before 18F-FDG PET scanning. The relationships were evaluated by means of statistical parametric mapping (SPM8). Results: Increased t-Tau CSF levels were related to reduced glucose consumption in a wide portion of the right frontal lobe [Brodmann area (BA 47)] and limbic lobe bilaterally (BA 31,32), whereas no areas of increased 18F-FDG uptake related to t-Tau levels were detected. Elevated p-Tau concentrations in CSF were related to increased glucose consumption in both the right and the left limbic lobe and in the left frontal lobe (BA 32 and 8). We did not find any specific cortical area of reduced glucose consumption being related to low levels of Aβ1-42 in CSF, whereas a spawn of 18F-FDG uptake was detectable in BA 18,19 and in the right cerebellum. Conclusion: The results of our study suggest that reduced Aβ1-42 concentrations in CSF are related to a wide cortical dysfunction, whereas t-Tau and p-Tau are related to more selective cortical metabolic patterns that mainly involve the cingulate cortex.

Original languageEnglish
Pages (from-to)461-468
Number of pages8
JournalNuclear Medicine Communications
Volume36
Issue number5
DOIs
Publication statusPublished - Apr 14 2015

Fingerprint

Fluorodeoxyglucose F18
Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Frontal Lobe
Glucose
Gyrus Cinguli
Cerebellum
Peptides
Brain

Keywords

  • Alzheimer
  • Amyloid
  • Cerebrospinal fluid biomarkers
  • Fluorine-18 fluorodeoxyglucose
  • PET
  • Tau

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Functional correlates of t-Tau, p-Tau and Aβ1-42 amyloid cerebrospinal fluid levels in Alzheimer's disease : A 18F-FDG PET/CT study. / Chiaravalloti, Agostino; Martorana, Alessandro; Koch, Giacomo; Toniolo, Sofia; Di Biagio, Daniele; Di Pietro, Barbara; Schillaci, Orazio.

In: Nuclear Medicine Communications, Vol. 36, No. 5, 14.04.2015, p. 461-468.

Research output: Contribution to journalArticle

Chiaravalloti, Agostino ; Martorana, Alessandro ; Koch, Giacomo ; Toniolo, Sofia ; Di Biagio, Daniele ; Di Pietro, Barbara ; Schillaci, Orazio. / Functional correlates of t-Tau, p-Tau and Aβ1-42 amyloid cerebrospinal fluid levels in Alzheimer's disease : A 18F-FDG PET/CT study. In: Nuclear Medicine Communications. 2015 ; Vol. 36, No. 5. pp. 461-468.
@article{abd14e68097644d7a38609415deb670a,
title = "Functional correlates of t-Tau, p-Tau and Aβ1-42 amyloid cerebrospinal fluid levels in Alzheimer's disease: A 18F-FDG PET/CT study",
abstract = "Aim: The aim of the study was to investigate the relationships between cerebrospinal fluid (CSF) levels of t-Tau, p-Tau and amyloid-β (Aβ1-42) amyloid peptide and fluorine-18 fluorodeoxyglucose (18F-FDG) brain distribution in a group of patients with Alzheimer's disease. Materials and methods: The study included 81 newly diagnosed Alzheimer's disease patients according to the NINCDS-ADRDA criteria. The mean (± SD) age of the patients was 70 (± 6) years; 44 were male and 37 were female. All patients underwent a CSF assay and MRI before 18F-FDG PET scanning. The relationships were evaluated by means of statistical parametric mapping (SPM8). Results: Increased t-Tau CSF levels were related to reduced glucose consumption in a wide portion of the right frontal lobe [Brodmann area (BA 47)] and limbic lobe bilaterally (BA 31,32), whereas no areas of increased 18F-FDG uptake related to t-Tau levels were detected. Elevated p-Tau concentrations in CSF were related to increased glucose consumption in both the right and the left limbic lobe and in the left frontal lobe (BA 32 and 8). We did not find any specific cortical area of reduced glucose consumption being related to low levels of Aβ1-42 in CSF, whereas a spawn of 18F-FDG uptake was detectable in BA 18,19 and in the right cerebellum. Conclusion: The results of our study suggest that reduced Aβ1-42 concentrations in CSF are related to a wide cortical dysfunction, whereas t-Tau and p-Tau are related to more selective cortical metabolic patterns that mainly involve the cingulate cortex.",
keywords = "Alzheimer, Amyloid, Cerebrospinal fluid biomarkers, Fluorine-18 fluorodeoxyglucose, PET, Tau",
author = "Agostino Chiaravalloti and Alessandro Martorana and Giacomo Koch and Sofia Toniolo and {Di Biagio}, Daniele and {Di Pietro}, Barbara and Orazio Schillaci",
year = "2015",
month = "4",
day = "14",
doi = "10.1097/MNM.0000000000000272",
language = "English",
volume = "36",
pages = "461--468",
journal = "Nuclear Medicine Communications",
issn = "0143-3636",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Functional correlates of t-Tau, p-Tau and Aβ1-42 amyloid cerebrospinal fluid levels in Alzheimer's disease

T2 - A 18F-FDG PET/CT study

AU - Chiaravalloti, Agostino

AU - Martorana, Alessandro

AU - Koch, Giacomo

AU - Toniolo, Sofia

AU - Di Biagio, Daniele

AU - Di Pietro, Barbara

AU - Schillaci, Orazio

PY - 2015/4/14

Y1 - 2015/4/14

N2 - Aim: The aim of the study was to investigate the relationships between cerebrospinal fluid (CSF) levels of t-Tau, p-Tau and amyloid-β (Aβ1-42) amyloid peptide and fluorine-18 fluorodeoxyglucose (18F-FDG) brain distribution in a group of patients with Alzheimer's disease. Materials and methods: The study included 81 newly diagnosed Alzheimer's disease patients according to the NINCDS-ADRDA criteria. The mean (± SD) age of the patients was 70 (± 6) years; 44 were male and 37 were female. All patients underwent a CSF assay and MRI before 18F-FDG PET scanning. The relationships were evaluated by means of statistical parametric mapping (SPM8). Results: Increased t-Tau CSF levels were related to reduced glucose consumption in a wide portion of the right frontal lobe [Brodmann area (BA 47)] and limbic lobe bilaterally (BA 31,32), whereas no areas of increased 18F-FDG uptake related to t-Tau levels were detected. Elevated p-Tau concentrations in CSF were related to increased glucose consumption in both the right and the left limbic lobe and in the left frontal lobe (BA 32 and 8). We did not find any specific cortical area of reduced glucose consumption being related to low levels of Aβ1-42 in CSF, whereas a spawn of 18F-FDG uptake was detectable in BA 18,19 and in the right cerebellum. Conclusion: The results of our study suggest that reduced Aβ1-42 concentrations in CSF are related to a wide cortical dysfunction, whereas t-Tau and p-Tau are related to more selective cortical metabolic patterns that mainly involve the cingulate cortex.

AB - Aim: The aim of the study was to investigate the relationships between cerebrospinal fluid (CSF) levels of t-Tau, p-Tau and amyloid-β (Aβ1-42) amyloid peptide and fluorine-18 fluorodeoxyglucose (18F-FDG) brain distribution in a group of patients with Alzheimer's disease. Materials and methods: The study included 81 newly diagnosed Alzheimer's disease patients according to the NINCDS-ADRDA criteria. The mean (± SD) age of the patients was 70 (± 6) years; 44 were male and 37 were female. All patients underwent a CSF assay and MRI before 18F-FDG PET scanning. The relationships were evaluated by means of statistical parametric mapping (SPM8). Results: Increased t-Tau CSF levels were related to reduced glucose consumption in a wide portion of the right frontal lobe [Brodmann area (BA 47)] and limbic lobe bilaterally (BA 31,32), whereas no areas of increased 18F-FDG uptake related to t-Tau levels were detected. Elevated p-Tau concentrations in CSF were related to increased glucose consumption in both the right and the left limbic lobe and in the left frontal lobe (BA 32 and 8). We did not find any specific cortical area of reduced glucose consumption being related to low levels of Aβ1-42 in CSF, whereas a spawn of 18F-FDG uptake was detectable in BA 18,19 and in the right cerebellum. Conclusion: The results of our study suggest that reduced Aβ1-42 concentrations in CSF are related to a wide cortical dysfunction, whereas t-Tau and p-Tau are related to more selective cortical metabolic patterns that mainly involve the cingulate cortex.

KW - Alzheimer

KW - Amyloid

KW - Cerebrospinal fluid biomarkers

KW - Fluorine-18 fluorodeoxyglucose

KW - PET

KW - Tau

UR - http://www.scopus.com/inward/record.url?scp=84927571653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927571653&partnerID=8YFLogxK

U2 - 10.1097/MNM.0000000000000272

DO - 10.1097/MNM.0000000000000272

M3 - Article

VL - 36

SP - 461

EP - 468

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 5

ER -