Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases

C. Babiloni, C. Del Percio, R. Lizio, G. Noce, S. Lopez, A. Soricelli, R. Ferri, M.T. Pascarelli, V. Catania, F. Nobili, D. Arnaldi, F. Famà, F. Orzi, C. Buttinelli, F. Giubilei, L. Bonanni, R. Franciotti, M. Onofrj, P. Stirpe, P. FuhrU. Gschwandtner, G. Ransmayr, H. Garn, L. Fraioli, M. Pievani, F. D'Antonio, C. De Lena, B. Güntekin, L. Hanoğlu, E. Başar, G. Yener, D.D. Emek-Savaş, A.I. Triggiani, J.P. Taylor, M.F. De Pandis, L. Vacca, G.B. Frisoni, F. Stocchi

Research output: Contribution to journalArticle

Abstract

Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70–0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. © 2018 International Federation of Clinical Neurophysiology
Original languageEnglish
Pages (from-to)766-782
Number of pages17
JournalClinical Neurophysiology
Volume129
Issue number4
DOIs
Publication statusE-pub ahead of print - Jan 31 2018

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Alpha Rhythm
Parkinson Disease
Alzheimer Disease
ROC Curve
Neurophysiology
Cholinergic Agents
Healthy Volunteers
Cognitive Dysfunction

Keywords

  • Functional brain connectivity
  • Mild cognitive impairment due to Alzheimer's disease (ADMCI)
  • Mild cognitive impairment due to Parkinson's disease (PDMCI)
  • Resting state EEG rhythms
  • aged
  • alpha rhythm
  • Alzheimer disease
  • Article
  • beta rhythm
  • brain cortex
  • controlled study
  • delta rhythm
  • diagnostic accuracy
  • diagnostic test accuracy study
  • disease classification
  • female
  • functional connectivity
  • human
  • major clinical study
  • male
  • mild cognitive impairment
  • Parkinson disease
  • priority journal
  • receiver operating characteristic
  • resting state network
  • retrospective study
  • theta rhythm

Cite this

Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases. / Babiloni, C.; Del Percio, C.; Lizio, R.; Noce, G.; Lopez, S.; Soricelli, A.; Ferri, R.; Pascarelli, M.T.; Catania, V.; Nobili, F.; Arnaldi, D.; Famà, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Bonanni, L.; Franciotti, R.; Onofrj, M.; Stirpe, P.; Fuhr, P.; Gschwandtner, U.; Ransmayr, G.; Garn, H.; Fraioli, L.; Pievani, M.; D'Antonio, F.; De Lena, C.; Güntekin, B.; Hanoğlu, L.; Başar, E.; Yener, G.; Emek-Savaş, D.D.; Triggiani, A.I.; Taylor, J.P.; De Pandis, M.F.; Vacca, L.; Frisoni, G.B.; Stocchi, F.

In: Clinical Neurophysiology, Vol. 129, No. 4, 31.01.2018, p. 766-782.

Research output: Contribution to journalArticle

Babiloni, C, Del Percio, C, Lizio, R, Noce, G, Lopez, S, Soricelli, A, Ferri, R, Pascarelli, MT, Catania, V, Nobili, F, Arnaldi, D, Famà, F, Orzi, F, Buttinelli, C, Giubilei, F, Bonanni, L, Franciotti, R, Onofrj, M, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Garn, H, Fraioli, L, Pievani, M, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Başar, E, Yener, G, Emek-Savaş, DD, Triggiani, AI, Taylor, JP, De Pandis, MF, Vacca, L, Frisoni, GB & Stocchi, F 2018, 'Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases', Clinical Neurophysiology, vol. 129, no. 4, pp. 766-782. https://doi.org/10.1016/j.clinph.2018.01.009
Babiloni, C. ; Del Percio, C. ; Lizio, R. ; Noce, G. ; Lopez, S. ; Soricelli, A. ; Ferri, R. ; Pascarelli, M.T. ; Catania, V. ; Nobili, F. ; Arnaldi, D. ; Famà, F. ; Orzi, F. ; Buttinelli, C. ; Giubilei, F. ; Bonanni, L. ; Franciotti, R. ; Onofrj, M. ; Stirpe, P. ; Fuhr, P. ; Gschwandtner, U. ; Ransmayr, G. ; Garn, H. ; Fraioli, L. ; Pievani, M. ; D'Antonio, F. ; De Lena, C. ; Güntekin, B. ; Hanoğlu, L. ; Başar, E. ; Yener, G. ; Emek-Savaş, D.D. ; Triggiani, A.I. ; Taylor, J.P. ; De Pandis, M.F. ; Vacca, L. ; Frisoni, G.B. ; Stocchi, F. / Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases. In: Clinical Neurophysiology. 2018 ; Vol. 129, No. 4. pp. 766-782.
@article{d9596310571f421184b0d31597d733cd,
title = "Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases",
abstract = "Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70–0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. {\circledC} 2018 International Federation of Clinical Neurophysiology",
keywords = "Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to Parkinson's disease (PDMCI), Resting state EEG rhythms, aged, alpha rhythm, Alzheimer disease, Article, beta rhythm, brain cortex, controlled study, delta rhythm, diagnostic accuracy, diagnostic test accuracy study, disease classification, female, functional connectivity, human, major clinical study, male, mild cognitive impairment, Parkinson disease, priority journal, receiver operating characteristic, resting state network, retrospective study, theta rhythm",
author = "C. Babiloni and {Del Percio}, C. and R. Lizio and G. Noce and S. Lopez and A. Soricelli and R. Ferri and M.T. Pascarelli and V. Catania and F. Nobili and D. Arnaldi and F. Fam{\`a} and F. Orzi and C. Buttinelli and F. Giubilei and L. Bonanni and R. Franciotti and M. Onofrj and P. Stirpe and P. Fuhr and U. Gschwandtner and G. Ransmayr and H. Garn and L. Fraioli and M. Pievani and F. D'Antonio and {De Lena}, C. and B. G{\"u}ntekin and L. Hanoğlu and E. Başar and G. Yener and D.D. Emek-Savaş and A.I. Triggiani and J.P. Taylor and {De Pandis}, M.F. and L. Vacca and G.B. Frisoni and F. Stocchi",
note = "Cited By :1 Export Date: 29 January 2019 CODEN: CNEUF Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer”, University of Rome “La Sapienza”, P. le A. 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year = "2018",
month = "1",
day = "31",
doi = "10.1016/j.clinph.2018.01.009",
language = "English",
volume = "129",
pages = "766--782",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "4",

}

TY - JOUR

T1 - Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases

AU - Babiloni, C.

AU - Del Percio, C.

AU - Lizio, R.

AU - Noce, G.

AU - Lopez, S.

AU - Soricelli, A.

AU - Ferri, R.

AU - Pascarelli, M.T.

AU - Catania, V.

AU - Nobili, F.

AU - Arnaldi, D.

AU - Famà, F.

AU - Orzi, F.

AU - Buttinelli, C.

AU - Giubilei, F.

AU - Bonanni, L.

AU - Franciotti, R.

AU - Onofrj, M.

AU - Stirpe, P.

AU - Fuhr, P.

AU - Gschwandtner, U.

AU - Ransmayr, G.

AU - Garn, H.

AU - Fraioli, L.

AU - Pievani, M.

AU - D'Antonio, F.

AU - De Lena, C.

AU - Güntekin, B.

AU - Hanoğlu, L.

AU - Başar, E.

AU - Yener, G.

AU - Emek-Savaş, D.D.

AU - Triggiani, A.I.

AU - Taylor, J.P.

AU - De Pandis, M.F.

AU - Vacca, L.

AU - Frisoni, G.B.

AU - Stocchi, F.

N1 - Cited By :1 Export Date: 29 January 2019 CODEN: CNEUF Correspondence Address: Babiloni, C.; Department of Physiology and Pharmacology “V. Erspamer”, University of Rome “La Sapienza”, P. le A. 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PY - 2018/1/31

Y1 - 2018/1/31

N2 - Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70–0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. © 2018 International Federation of Clinical Neurophysiology

AB - Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70–0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. © 2018 International Federation of Clinical Neurophysiology

KW - Functional brain connectivity

KW - Mild cognitive impairment due to Alzheimer's disease (ADMCI)

KW - Mild cognitive impairment due to Parkinson's disease (PDMCI)

KW - Resting state EEG rhythms

KW - aged

KW - alpha rhythm

KW - Alzheimer disease

KW - Article

KW - beta rhythm

KW - brain cortex

KW - controlled study

KW - delta rhythm

KW - diagnostic accuracy

KW - diagnostic test accuracy study

KW - disease classification

KW - female

KW - functional connectivity

KW - human

KW - major clinical study

KW - male

KW - mild cognitive impairment

KW - Parkinson disease

KW - priority journal

KW - receiver operating characteristic

KW - resting state network

KW - retrospective study

KW - theta rhythm

U2 - 10.1016/j.clinph.2018.01.009

DO - 10.1016/j.clinph.2018.01.009

M3 - Article

VL - 129

SP - 766

EP - 782

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 4

ER -