Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases

C. Babiloni, C. Del Percio, R. Lizio, G. Noce, S. Lopez, A. Soricelli, R. Ferri, M.T. Pascarelli, V. Catania, F. Nobili, D. Arnaldi, F. Famà, F. Orzi, C. Buttinelli, F. Giubilei, L. Bonanni, R. Franciotti, M. Onofrj, P. Stirpe, P. FuhrU. Gschwandtner, G. Ransmayr, H. Garn, L. Fraioli, M. Pievani, F. D'Antonio, C. De Lena, B. Güntekin, L. Hanoğlu, E. Başar, G. Yener, D.D. Emek-Savaş, A.I. Triggiani, J.P. Taylor, M.F. De Pandis, L. Vacca, G.B. Frisoni, F. Stocchi

Research output: Contribution to journalArticle

Abstract

Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70–0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. © 2018 International Federation of Clinical Neurophysiology
Original languageEnglish
Pages (from-to)766-782
Number of pages17
JournalClinical Neurophysiology
Volume129
Issue number4
DOIs
Publication statusE-pub ahead of print - Jan 31 2018

Keywords

  • Functional brain connectivity
  • Mild cognitive impairment due to Alzheimer's disease (ADMCI)
  • Mild cognitive impairment due to Parkinson's disease (PDMCI)
  • Resting state EEG rhythms
  • aged
  • alpha rhythm
  • Alzheimer disease
  • Article
  • beta rhythm
  • brain cortex
  • controlled study
  • delta rhythm
  • diagnostic accuracy
  • diagnostic test accuracy study
  • disease classification
  • female
  • functional connectivity
  • human
  • major clinical study
  • male
  • mild cognitive impairment
  • Parkinson disease
  • priority journal
  • receiver operating characteristic
  • resting state network
  • retrospective study
  • theta rhythm

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