Functional dichotomy of CD4+ T helper lymphocytes in asymptomatic human immunodeficiency virus infection

Mario Clerici, Charles S. Via, Daniel R. Lucey, Emmanuel Roilides, Philip A. Pizzo, Gene M. Shearer

Research output: Contribution to journalArticle

Abstract

The majority of asymptomatic, human immune deficiency virus seropositive (HIV+) individuals exhibit a defect in CD4+ T helper cell (Th) function that is selective for responses to recall antigens, but not to HLA alloantigens. The CD4-dependent Th response to HLA alloantigens (Allo) can be mediated by two distinct Th pathways: self-restricted CD4+ Th that recognize allogeneic determinants processed and presented by autologous or self accessory or antigen-presenting cells (sAC); and allo-restricted, CD4+ Th that recognize allogeneic determinants directly on allogeneic accessory or antigen-presenting cells (aAC). In contrast, the Th response to recall antigens requires CD4+ Th and s AC and is therefore limited to the major histocompatibility complex (MHC) self-restricted pathway. Peripheral blood leukocytes from 56 asymptomatic HIV+ patients that exhibited a selective defect in CD4+ Th function were analyzed to determine whether the Th response to Allo was entirely functional, or whether one of the CD4-mediated components of the Allo Th response was also defective. By depletion of AC and/or CD8+ Th subsets (to analyze CD4+ Th function), we demonstrated that HIV+ patients who were selectively deficient in Th function to recall antigens were also unresponsive to Allo presented by autologous AC (HLA self-restricted Th pathway), but retained Allo Th activity presented by allogeneic AC (allo-restricted CD4+ Th pathway).These findings indicate that the CD4+ Th defect seen in the majority of asymptomatic, HIV+ individuals is not limited to recall antigens, but also extends to the component of the response to HLA alloantigens that involves the self-restricted, CD4+ Th pathway. Thus, the Th defect observed in asymptomatic, HIV+ patients does not involve a CD4+ Th defect per se, but is limited to the HLA self-restricted component of Th function.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalEuropean Journal of Immunology
Volume21
Issue number3
Publication statusPublished - Mar 1991

ASJC Scopus subject areas

  • Immunology

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    Clerici, M., Via, C. S., Lucey, D. R., Roilides, E., Pizzo, P. A., & Shearer, G. M. (1991). Functional dichotomy of CD4+ T helper lymphocytes in asymptomatic human immunodeficiency virus infection. European Journal of Immunology, 21(3), 665-670.