Functional dyspepsia: Pathogenesis and treatment

R. Barbera, G. Basilisco

Research output: Contribution to journalArticlepeer-review


Functional dyspepsia is a common clinical condition in which the symptoms related mainly to the upper gastrointestinal tract and associated by the patients with meals are not related to any organic disease. The pathophysiology of functional dyspepsia is still not well understood, and the patients are subdivided into distinct subgroups on the basis of the symptoms. These subgroups include patients with symptoms suggestive of motor abnormalities of the upper gut, patients with symptoms of gastroesophageal reflux and patients with symptoms mimicking a peptic ulcer condition. Recently the clinical importance of these subgroups has become less accepted, as they seem not to help in planning the therapeutic management of the patients. In the present review, we critically discuss the pathogenic mechanisms behind the subgroups subdivision. Moreover, the more recent hypothesis of an abnormal visceral sensitivity as the major mechanism responsible for symptoms is further discussed. The results of these new data might change the therapeutic approach to this condition.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalOspedale Maggiore
Issue number1
Publication statusPublished - 1995


  • CCK
  • functional dyspepsia
  • lipid-hypersensitivity
  • mechano-hypersensitivity

ASJC Scopus subject areas

  • Medicine(all)


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