Functional dyspepsia symptoms, gastric emptying and satiety provocative test: Analysis of relationships

R. Cuomo, G. Sarnelli, R. Grasso, D. Bruzzese, R. Pumpo, M. Salomone, E. Nicolai, J. Tack, G. Budillon

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background: The correlation between symptoms and observed impaired function in functional dyspepsia is still inconsistent. The aims of the study were to obtain a measure of satiety by a meal test; to verify whether this compares with severity of symptoms assessed using a reproducible questionnaire; and to correlate the parameters of satiety test and gastric emptying with all the dyspeptic symptoms. Methods: Fifty-two functional dyspepsia patients reported their symptoms on a standardized questionnaire that considered belching, bloating, early satiety, epigastric pain and burning, nausea, postprandial fullness and vomiting. They were monitored for gastric emptying of a solid caloric meal using a radionuclide technique and underwent a test to quantify meal-induced satiety by a liquid caloric meal. Results: The number of kilocalories ingested during the satiety test until the occurrence of maximum satiety in healthy subjects was 110% higher than in the dyspeptic group (mean ± s: 1110 ± 23 versus 532 ± 56; P <0.01). We found a significant positive correlation between gastric emptying rate and kcal of the satiety test (P <0.01; r = 0.428). Logistic regression showed a significant inverse association between severity of early satiety-coded as absent, mild, moderate or severe, kcal of meal test (P = 0.01), and gastric emptying lag phase (P=0.03). Bloating was associated directly with t1/2 of gastric emptying (P = 0.03) and inversely with lag phase (P = 0.02). Conclusions: The satiety test gives a fine numerical measure of satiety and confirms the results of a symptoms qnestionnaire. Our study showed an indirect correlation between severity of early satiety - as measured by the satiety test, and gastric emptying rate, as well as an association between bloating and delayed gastric emptying.

Original languageEnglish
Pages (from-to)1030-1036
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume36
Issue number10
DOIs
Publication statusPublished - 2001

Fingerprint

Dyspepsia
Gastric Emptying
Meals
Eructation
Radioisotopes
Nausea
Vomiting
Healthy Volunteers
Logistic Models
Pain

Keywords

  • Bloating
  • Dyspepsia
  • Early satiety
  • Gastric emptying
  • Satiety test

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cuomo, R., Sarnelli, G., Grasso, R., Bruzzese, D., Pumpo, R., Salomone, M., ... Budillon, G. (2001). Functional dyspepsia symptoms, gastric emptying and satiety provocative test: Analysis of relationships. Scandinavian Journal of Gastroenterology, 36(10), 1030-1036. https://doi.org/10.1080/003655201750422611

Functional dyspepsia symptoms, gastric emptying and satiety provocative test : Analysis of relationships. / Cuomo, R.; Sarnelli, G.; Grasso, R.; Bruzzese, D.; Pumpo, R.; Salomone, M.; Nicolai, E.; Tack, J.; Budillon, G.

In: Scandinavian Journal of Gastroenterology, Vol. 36, No. 10, 2001, p. 1030-1036.

Research output: Contribution to journalArticle

Cuomo, R, Sarnelli, G, Grasso, R, Bruzzese, D, Pumpo, R, Salomone, M, Nicolai, E, Tack, J & Budillon, G 2001, 'Functional dyspepsia symptoms, gastric emptying and satiety provocative test: Analysis of relationships', Scandinavian Journal of Gastroenterology, vol. 36, no. 10, pp. 1030-1036. https://doi.org/10.1080/003655201750422611
Cuomo, R. ; Sarnelli, G. ; Grasso, R. ; Bruzzese, D. ; Pumpo, R. ; Salomone, M. ; Nicolai, E. ; Tack, J. ; Budillon, G. / Functional dyspepsia symptoms, gastric emptying and satiety provocative test : Analysis of relationships. In: Scandinavian Journal of Gastroenterology. 2001 ; Vol. 36, No. 10. pp. 1030-1036.
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