Functional dyspepsia symptoms, gastric emptying and satiety provocative test: Analysis of relationships

R. Cuomo, G. Sarnelli, R. Grasso, D. Bruzzese, R. Pumpo, M. Salomone, E. Nicolai, J. Tack, G. Budillon

Research output: Contribution to journalArticle


Background: The correlation between symptoms and observed impaired function in functional dyspepsia is still inconsistent. The aims of the study were to obtain a measure of satiety by a meal test; to verify whether this compares with severity of symptoms assessed using a reproducible questionnaire; and to correlate the parameters of satiety test and gastric emptying with all the dyspeptic symptoms. Methods: Fifty-two functional dyspepsia patients reported their symptoms on a standardized questionnaire that considered belching, bloating, early satiety, epigastric pain and burning, nausea, postprandial fullness and vomiting. They were monitored for gastric emptying of a solid caloric meal using a radionuclide technique and underwent a test to quantify meal-induced satiety by a liquid caloric meal. Results: The number of kilocalories ingested during the satiety test until the occurrence of maximum satiety in healthy subjects was 110% higher than in the dyspeptic group (mean ± s: 1110 ± 23 versus 532 ± 56; P <0.01). We found a significant positive correlation between gastric emptying rate and kcal of the satiety test (P <0.01; r = 0.428). Logistic regression showed a significant inverse association between severity of early satiety-coded as absent, mild, moderate or severe, kcal of meal test (P = 0.01), and gastric emptying lag phase (P=0.03). Bloating was associated directly with t1/2 of gastric emptying (P = 0.03) and inversely with lag phase (P = 0.02). Conclusions: The satiety test gives a fine numerical measure of satiety and confirms the results of a symptoms qnestionnaire. Our study showed an indirect correlation between severity of early satiety - as measured by the satiety test, and gastric emptying rate, as well as an association between bloating and delayed gastric emptying.

Original languageEnglish
Pages (from-to)1030-1036
Number of pages7
JournalScandinavian Journal of Gastroenterology
Issue number10
Publication statusPublished - 2001


  • Bloating
  • Dyspepsia
  • Early satiety
  • Gastric emptying
  • Satiety test

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Functional dyspepsia symptoms, gastric emptying and satiety provocative test: Analysis of relationships'. Together they form a unique fingerprint.

  • Cite this

    Cuomo, R., Sarnelli, G., Grasso, R., Bruzzese, D., Pumpo, R., Salomone, M., Nicolai, E., Tack, J., & Budillon, G. (2001). Functional dyspepsia symptoms, gastric emptying and satiety provocative test: Analysis of relationships. Scandinavian Journal of Gastroenterology, 36(10), 1030-1036.