Functional evaluation of the basophil/IgE system in the cord blood

A. Miadonna, A. Tedeschi, E. Leggieri, G. Motta, C. Fabbri, M. Froldi, M. Agosti, M. Lorini, A. Marini, C. Zanussi

Research output: Contribution to journalArticle

Abstract

Basophil releasability was studied in 24 cord blood samples from normal-term deliveries. The histamine content in cord blood basophils was similar to that of adult blood basophils. The response to IgE-independent degranulating stimuli such as calcium ionophore A23187 and zymosan-activated human serum was overlapping with that of normal adults. Conversely, a reduced releasability was observed after challenge with anti-IgE, even after sensitization with an IgE-rich serum. The IgE-dependent degranulation seems to be hampered by the low concentrations of circulating and cell-bound IgE antibodies. The number of IgE molecules bound to the specific receptors in cord blood basophils is significantly lower than in adult blood basophils.

Original languageEnglish
Pages (from-to)276-283
Number of pages8
JournalInternational Archives of Allergy and Applied Immunology
Volume81
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology and Allergy

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    Miadonna, A., Tedeschi, A., Leggieri, E., Motta, G., Fabbri, C., Froldi, M., Agosti, M., Lorini, M., Marini, A., & Zanussi, C. (1986). Functional evaluation of the basophil/IgE system in the cord blood. International Archives of Allergy and Applied Immunology, 81(3), 276-283.