Functional genomics, new tools in malaria research

Francesco Di Girolamo, Carla Raggi, Emanuele Bultrini, Alessandra Lanfrancotti, Francesco Silvestrini, Massimo Sargiacomo, Cecilia Birago, Elisabetta Pizzi, Pietro Alano, Marta Ponzi

Research output: Contribution to journalArticlepeer-review


The mosquito-transmitted unicellular parasite Plasmodium falciparum, the agent of malaria disease, still causes more than one million deaths every year in the tropical and subtropical areas of the world. New intervention strategies are needed to contrast the insurgence of resistance to effective drugs and insecticides. The complete annotated genomes of the human parasite P. falciparum and the rodent model P. yoelii is now available thus providing a prediction of their possible gene products. This makes feasible the application of functional genomics to malaria research with the final goal of providing a complete survey of Plasmodium life cycle. Genome-wide approaches to the study of transcriptome or proteome were successfully applied to malaria parasite with the promise for new drug and vaccine candidates in the next future.

Original languageEnglish
Pages (from-to)469-477
Number of pages9
JournalAnnali dell'Istituto Superiore di Sanita
Issue number4
Publication statusPublished - 2005


  • Bioinformatics
  • Plasmodium
  • Proteome
  • Transcriptome

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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