Functional genomics of the inflammatory response: Where are we now?

Marta Simonatto, Gioacchino Natoli

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation is a tightly regulated process that is achieved through the specific and controlled activation of innate immune system cells, notably neutrophils, macrophages and dendritic cells. Functional genomics studies in the last years have contributed to an integrated picture of the events controlling macrophage specialization and plasticity. Here we will summarize recent advances in the characterization of themolecular determinants of macrophage functional properties, and specifically how the interplay between genomic and epigenomic information, transcription factors and micro-environmental cues results in a fine-tuned transcriptional response.

Original languageEnglish
Article numberelt023
Pages (from-to)483-488
Number of pages6
JournalBriefings in Functional Genomics
Volume12
Issue number6
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Chromatin
  • Epigenetics
  • Inflammation
  • Macrophages
  • Transcription
  • Transcription factors

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

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