Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease

E. Savarino, D. Pohl, P. Zentilin, P. Dulbecco, G. Sammito, L. Sconfienza, S. Vigneri, G. Camerini, R. Tutuian, V. Savarino

Research output: Contribution to journalArticlepeer-review


Introduction: Functional dyspepsia and non-erosive reflux disease (NERD) are prevalent gastrointestinal conditions with accumulating evidence regarding an overlap between the two. Still, patients with NERD represent a very heterogeneous group and limited data on dyspeptic symptoms in various subgroups of NERD are available. Aim: To evaluate the prevalence of dyspeptic symptoms in patients with NERD subclassified by using 24 h impedance-pH monitoring (MII-pH). Methods: Patients with typical reflux symptoms and normal endoscopy underwent impedance-pH monitoring off proton pump inhibitor treatment. Oesophageal acid exposure time (AET), type of acid and non-acid reflux episodes, and symptom association probability (SAP) were calculated. A validated dyspepsia questionnaire was used to quantify dyspeptic symptoms prior to reflux monitoring. Results: Of 200 patients with NERD (105 female; median age, 48 years), 81 (41%) had an abnormal oesophageal AET (NERD pH-POS), 65 (32%) had normal oesophageal AET and positive SAP for acid and/or non-acid reflux (hypersensitive oesophagus), and 54 (27%) had normal oesophageal AET and negative SAP (functional heartburn). Patients with functional heartburn had more frequent (p

Original languageEnglish
Pages (from-to)1185-1191
Number of pages7
Issue number9
Publication statusPublished - Sep 2009

ASJC Scopus subject areas

  • Gastroenterology


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