Abstract
Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.
| Original language | English |
|---|---|
| Article number | 2371824 |
| Pages (from-to) | 667-678 |
| Number of pages | 12 |
| Journal | IEEE/ACM Transactions on Computational Biology and Bioinformatics |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1 2015 |
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Keywords
- Autophagy
- Network topology
- Pancreatic cancer
- Starvation
ASJC Scopus subject areas
- Biotechnology
- Genetics
- Applied Mathematics
Cite this
Functional impact of autophagy-related genes on the homeostasis and dynamics of pancreatic cancer cell lines. / Mazza, Tommaso; Fusilli, Caterina; Saracino, Chiara; Mazzoccoli, Gianluigi; Tavano, Francesca; Vinciguerra, Manlio; Pazienza, Valerio.
In: IEEE/ACM Transactions on Computational Biology and Bioinformatics, Vol. 12, No. 3, 2371824, 01.05.2015, p. 667-678.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functional impact of autophagy-related genes on the homeostasis and dynamics of pancreatic cancer cell lines
AU - Mazza, Tommaso
AU - Fusilli, Caterina
AU - Saracino, Chiara
AU - Mazzoccoli, Gianluigi
AU - Tavano, Francesca
AU - Vinciguerra, Manlio
AU - Pazienza, Valerio
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.
AB - Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.
KW - Autophagy
KW - Network topology
KW - Pancreatic cancer
KW - Starvation
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UR - http://www.scopus.com/inward/citedby.url?scp=84940384419&partnerID=8YFLogxK
U2 - 10.1109/TCBB.2014.2371824
DO - 10.1109/TCBB.2014.2371824
M3 - Article
C2 - 26357277
AN - SCOPUS:84940384419
VL - 12
SP - 667
EP - 678
JO - IEEE/ACM Transactions on Computational Biology and Bioinformatics
JF - IEEE/ACM Transactions on Computational Biology and Bioinformatics
SN - 1545-5963
IS - 3
M1 - 2371824
ER -