Functional impact of autophagy-related genes on the homeostasis and dynamics of pancreatic cancer cell lines

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.

Original languageEnglish
Article number2371824
Pages (from-to)667-678
Number of pages12
JournalIEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume12
Issue number3
DOIs
Publication statusPublished - May 1 2015

Fingerprint

Homeostasis
Autophagy
Pancreatic Neoplasms
Cancer
Genes
Cells
Gene
Cell Line
Line
Cell
Starvation
Chemotherapy
Tumor Growth
Network Analysis
Electric network analysis
Correlate
Tumors
Treatment Failure
Neoplasms
Scenarios

Keywords

  • Autophagy
  • Network topology
  • Pancreatic cancer
  • Starvation

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Applied Mathematics

Cite this

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abstract = "Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.",
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AU - Mazza, Tommaso

AU - Fusilli, Caterina

AU - Saracino, Chiara

AU - Mazzoccoli, Gianluigi

AU - Tavano, Francesca

AU - Vinciguerra, Manlio

AU - Pazienza, Valerio

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AB - Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.

KW - Autophagy

KW - Network topology

KW - Pancreatic cancer

KW - Starvation

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