Functional impact of autophagy-related genes on the homeostasis and dynamics of pancreatic cancer cell lines

Tommaso Mazza, Caterina Fusilli, Chiara Saracino, Gianluigi Mazzoccoli, Francesca Tavano, Manlio Vinciguerra, Valerio Pazienza

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer is a highly aggressive and chemotherapy-resistant malignant neoplasm. In basal condition, it is characterized by elevated autophagy activity, which is required for tumor growth and that correlates with treatment failure. We analyzed the expression of autophagy related genes in different pancreatic cancer cell lines. A correlation-based network analysis evidenced the sociality and topological roles of the autophagy-related genes after serum starvation. Structural and functional tests identified a core set of autophagy related genes, suggesting different scenarios of autophagic responses to starvation, which may be responsible for the clinical variations associated with pancreatic cancer pathogenesis.

Original languageEnglish
Article number2371824
Pages (from-to)667-678
Number of pages12
JournalIEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume12
Issue number3
DOIs
Publication statusPublished - May 1 2015

Keywords

  • Autophagy
  • Network topology
  • Pancreatic cancer
  • Starvation

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Applied Mathematics

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